Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 3 Picks.
| Away | Home | Location | Cecil | Joe |
| Tennessee | Jacksonville | TIAA Bank Field, Jacksonville | Titans | Titans |
| Cincinnati | Buffalo | New Era Field, Buffalo | Bills | Bills |
| Miami | Dallas | AT&T Stadium, Arlington | Cowboys | Cowboys |
| Denver | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
| Atlanta | Indianapolis | Lucas Oil Stadium, Indianapolis | Falcons | Falcons |
| Baltimore | Kansas City | Arrowhead Stadium, Kansas City | Chiefs | Chiefs |
| Oakland | Minnesota | U.S. Bank Stadium, Minneapolis | Vikings | Vikings |
| New York Jets | New England | Gillette Stadium, Foxboro | Patriots | Patriots |
| Detroit | Philadelphia | Lincoln Financial Field, Philadelphia | Eagles | Eagles |
| Carolina | Arizona | State Farm Stadium, Glendale | Panthers | Panthers |
| New York Giants | Tampa Bay | Raymond James Stadium, Tampa | Bucs | Bucs |
| Houston | Los Angeles Chargers | Dignity Health Sports Park, Carson | Texans | Chargers |
| Pittsburgh | San Francisco | Levi’s Stadium, Santa Clara | 49ers | 49ers |
| New Orleans | Seattle | CenturyLink Field, Seattle | Saints | Seahawks |
| Los Angeles Rams | Cleveland | FirstEnergy Stadium, Cleveland | Rams | Rams |
| Chicago | Washington | FedEx Field, Landover | Bears | Bears |
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