Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 11 picks.
| Away | Home | Location | Cecil | Joe |
| Pittsburgh | Cleveland | FirstEnergy Stadium, Cleveland | Steelers | Steelers |
| Dallas | Detroit | Ford Field, Detroit | Cowboys | Cowboys |
| Jacksonville | Indianapolis | Lucas Oil Stadium, Indianapolis | Jags | Jags |
| Buffalo | Miami | Hard Rock Stadium, Miami Gardens | Bills | Bills |
| Denver | Minnesota | U.S. Bank Stadium, Minneapolis | Vikings | Vikings |
| New Orleans | Tampa Bay | Raymond James Stadium, Tampa | Saints | Saints |
| New York Jets | Washington | FedEx Field, Landover | Jets | Redskins |
| Atlanta | Carolina | Bank of America Stadium, Charlotte | Panthers | Panthers |
| Houston | Baltimore | M&T Bank Stadium, Baltimore | Ravens | Ravens |
| Arizona | San Francisco | Levi’s Stadium, Santa Clara | 49ers | 49ers |
| Cincinnati | Oakland | RingCentral Coliseum, Oakland | Raiders | Raiders |
| New England | Philadelphia | Lincoln Financial Field, Philadelphia | Patriots | Patriots |
| Chicago | Los Angeles Rams | Los Angeles Memorial Coliseum, Los Angeles | Rams | Rams |
| Kansas City | Los Angeles Chargers | Estadio Azteca, Mexico City | Chiefs | Chargers |
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