Cecil Walker (The Third) and Joe DiTullio (The Don) make their week 16 NFL picks. Regular picks are worth one point, weekend prime-time games are two points and upset picks (will be marked) are worth three points.
| Away Team | Home Team | Joe | Cecil |
| New York Giants | Philadelphia Eagles | Giants | Giants |
| Miami Dolphins | Buffalo Bills | Dolphins | Bills |
| New York Jets | New England Patriots | Patriots | Patriots |
| Tennessee Titans | Jacksonville Jaguars | Titans | Titans |
| Minnesota Vikings | Green Bay Packers | Packers | Packers |
| San Diego Chargers | Cleveland Browns | Chargers | Chargers |
| Washington Redskins | Chicago Bears | Bears | Bears |
| Atlanta Falcons | Carolina Panthers | Panthers | Falcons |
| Indianapolis Colts | Oakland Raiders | Raiders | Raiders |
| Tampa Bay Buccaneers | New Orleans Saints | Saints | Bucs |
| Arizona Cardinals | Seattle Seahawks | Seahawks | Seahawks |
| San Francisco 49ers | Los Angeles Rams | Buccaneers | 49ers |
| Cincinnati Bengals | Houston Texans | Bengals | Bengals |
| Baltimore Ravens | Pittsburgh Steelers | Steelers | Steelers |
| Denver Broncos | Kansas City Chiefs | Chiefs | Chiefs |
| Detroit Lions | Dallas Cowboys | Cowboys | Cowboys |
| Season Total | 140 | 132 |