Cecil Walker (The Third) and Joe DiTullio (The Don) make their week 16 NFL picks. Regular picks are worth one point, weekend prime-time games are two points and upset picks (will be marked) are worth three points.
| Away Team | Home Team | Joe | Cecil |
| New York Giants | Philadelphia Eagles | Giants | Giants |
| Miami Dolphins | Buffalo Bills | Dolphins | Bills |
| New York Jets | New England Patriots | Patriots | Patriots |
| Tennessee Titans | Jacksonville Jaguars | Titans | Titans |
| Minnesota Vikings | Green Bay Packers | Packers | Packers |
| San Diego Chargers | Cleveland Browns | Chargers | Chargers |
| Washington Redskins | Chicago Bears | Bears | Bears |
| Atlanta Falcons | Carolina Panthers | Panthers | Falcons |
| Indianapolis Colts | Oakland Raiders | Raiders | Raiders |
| Tampa Bay Buccaneers | New Orleans Saints | Saints | Bucs |
| Arizona Cardinals | Seattle Seahawks | Seahawks | Seahawks |
| San Francisco 49ers | Los Angeles Rams | Buccaneers | 49ers |
| Cincinnati Bengals | Houston Texans | Bengals | Bengals |
| Baltimore Ravens | Pittsburgh Steelers | Steelers | Steelers |
| Denver Broncos | Kansas City Chiefs | Chiefs | Chiefs |
| Detroit Lions | Dallas Cowboys | Cowboys | Cowboys |
| Season Total | 140 | 132 |
Players must be 21 years of age or older or reach the minimum age for gambling in their respective state and located in jurisdictions where online gambling is legal. Please play responsibly. Bet with your head, not over it. If you or someone you know has a gambling problem, and wants help, call or visit: (a) the Council on Compulsive Gambling of New Jersey at 1-800-Gambler or www.800gambler.org; or (b) Gamblers Anonymous at 855-2-CALL-GA or www.gamblersanonymous.org.
