The NFL season is already full of surprises, which makes it hard to pick winners. Cecil Walker and Joe DiTullio, of The Third and the Don Football Show, will do their best to try to predict the winners for every NFL game this season. Here are the NFL week 4 picks.
| Away | Home | Location | Joe | Cecil |
| Minnesota | Los Angeles Rams | Los Angeles Memorial Coliseum, Los Angeles | Rams | Rams |
| Cincinnati | Atlanta | Mercedes-Benz Stadium, Atlanta | Falcons | Falcons |
| Tampa Bay | Chicago | Soldier Field, Chicago | Bears | Bears |
| Detroit | Dallas | AT&T Stadium, Arlington | Lions | Lions |
| Buffalo | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
| Philadelphia | Tennessee | Nissan Stadium, Nashville | Eagles | Eagles |
| Houston | Indianapolis | Lucas Oil Stadium, Indianapolis | Colts | Texans |
| Miami | New England | Gillette Stadium, Foxboro | Pats | Pats |
| New York Jets | Jacksonville | TIAA Bank Field, Jacksonville | Jags | Jags |
| Cleveland | Oakland | Oakland Coliseum, Oakland | Raiders | Raiders |
| Seattle | Arizona | U of Phoenix Stadium, Glendale | Seahawks | Seahawks |
| New Orleans | New York Giants | MetLife Stadium, East Rutherford | Saints | Saints |
| San Francisco | Los Angeles | StubHub Center, Carson | Chargers | Chargers |
| Baltimore | Pittsburgh | Heinz Field, Pittsburgh | Steelers | Ravens |
| Kansas City | Denver | Broncos Stadium at Mile High, Denver | Chiefs | Chiefs |
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