Joe DiTullio and Rob Doerger of the DiTullio and Doerger College Sports Show make their picks for every FBS college football game. With a lot of good matchups in week two, let’s get to the picks.
| Away | Home | Location | Rob | Joe |
| Idaho State | Utah State | Romney Stadium, Logan, UT | Utah St | Utah St |
| #10 Oklahoma State | South Alabama | Ladd-Peebles Stadium, Mobile, AL | OK St | Ok St |
| Ohio | Purdue | Ross-Ade Stadium, West Lafayette, IN | Purdue | Purdue |
| Florida Atlantic | #9 Wisconsin | Camp Randall Stadium, Madison, WI | Wisc | Wisc |
| Cincinnati | #11 Michigan | Michigan Stadium, Ann Arbor, MI | Michigan | Michigan |
| #16 Louisville | North Carolina | Kenan Stadium, Chapel Hill, NC | Louisville | Louisville |
| #19 South Florida | Connecticut | Rentschler Field, East Hartford, CT | USF | USF |
| Charlotte | #20 Kansas State | Bill Snyder Family Stadium, Manhattan, KS | K State | K State |
| East Carolina | #22 West Virginia | Milan Puskar Stadium, Morgantown, WV | WVU | WVU |
| Northwestern | Duke | Wallace Wade Stadium, Durham, NC | NW | NW |
| Buffalo | Army | Michie Stadium, West Point, NY | Army | Army |
| Towson | Maryland | Maryland Stadium, College Park, MD | Maryland | Maryland |
| Eastern Kentucky | Kentucky | Commonwealth Stadium, Lexington, KY | UK | UK |
| UT Martin | Ole Miss | Vaught-Hemingway Stadium, Oxford, MS | Ole Miss | Ole Miss |
| Iowa | Iowa State | Jack Trice Stadium, Ames, IA | Iowa St | Iowa |
| Jacksonville State | Georgia Tech | Bobby Dodd Stadium, Atlanta, GA | GT | GT |
| Wake Forest | Boston College | Alumni Stadium , Chestnut Hill, MA | Wake | BC |
| Texas State | Colorado | Folsom Field, Boulder, CO | Colorado | Colorado |
| UAB | Ball State | Scheumann Stadium, Muncie, IN | Ball St | Ball St |
| Fresno State | #1 Alabama | Bryant-Denny Stadium, Tuscaloosa, AL | Bama | Bama |
| Margin of Victory | 37 | 43 | ||
| Pittsburgh | #6 Penn State | Beaver Stadium, University Park, PA | Penn St | Penn St |
| #18 Miami | Arkansas State | Centennial Bank Stadium, Jonesboro, AR | Miami | Miami |
| Delaware | #21 Virginia Tech | Lane Stadium, Blacksburg, VA | VT | Va Tech |
| San José State | #23 Texas | Royal Texas Memorial Stadium, Austin, TX | Texas | Texas |
| Tulane | Navy | Navy-Marine Corps Memorial Stadium, Annapolis, MD | Navy | Navy |
| Villanova | Temple | Lincoln Financial Field, Philadelphia, PA | Temple | Temple |
| Savannah State | Appalachian State | Kidd Brewer Stadium, Boone, NC | App St | App St |
| Abilene Christian | Colorado State | CSU Stadium, Fort Collins, CO | Col St | Colorado St |
| Austin Peay | Miami (OH) | Yager Stadium, Oxford, OH | Miami (OH) | Miami (OH) |
| Eastern Illinois | Northern Illinois | Huskie Stadium, DeKalb, IL | NIU | NIU |
| Howard | Kent State | Dix Stadium, Kent, OH | Kent St | Kent State |
| Indiana | Virginia | Scott Stadium, Charlottesville, VA | Indiana | Indiana |
| Middle Tennessee | Syracuse | Carrier Dome, Syracuse, NY | MTSU | MTSU |
| Old Dominion | UMass | Warren McGuirk Alumni Stadium, Amherst, MA | Old Dom | ODU |
| Western Michigan | Michigan State | Spartan Stadium , East Lansing, MI | Mich St | MSU |
| Eastern Michigan | Rutgers | High Point Solutions Stadium, Piscataway, NJ | Rutgers | Rutgers |
| TCU | Arkansas | Razorback Stadium, Fayetteville, AR | TCU | Arkansas |
| Indiana State | #25 Tennessee | Neyland Stadium, Knoxville, TN | Tenn | Tenn |
| Central Michigan | Kansas | Memorial Stadium , Lawrence, KS | Kansas | Kansas |
| Alabama A&M | Vanderbilt | Vanderbilt Stadium, Nashville, TN | Vandy | Vandy |
| Gardner-Webb | Wyoming | War Memorial Stadium , Laramie, WY | Wyoming | Wyoming |
| Louisiana | Tulsa | Chapman Stadium, Tulsa, OK | Tulsa | Tulsa |
| Nebraska | Oregon | Autzen Stadium, Eugene, OR | Ducks | Oregon |
| Hawai’i | UCLA | Rose Bowl, Pasadena, CA | UCLA | UCLA |
| Weber State | California | Memorial Stadium , Berkeley, CA | Cal | Cal |
| Marshall | NC State | Carter-Finley Stadium, Raleigh, NC | NC State | NC State |
| New Hampshire | Georgia Southern | Allen E. Paulson Stadium, Statesboro, GA | GSU | GSU |
| Alabama State | Troy | Veterans Memorial Stadium , Troy, AL | Troy | Troy |
| South Dakota | Bowling Green | Doyt Perry Stadium, Bowling Green, OH | BG | BG |
| Arkansas-Pine Bluff | Akron | InfoCision Stadium, Akron, OH | Akron | Akron |
| Louisiana Monroe | #3 Florida State | Doak Campbell Stadium, Tallahassee, FL | FSU | FSU |
| #12 Auburn | #5 Clemson | Memorial Stadium , Clemson, SC | Clemson | Clemson |
| Toledo | Nevada | Mackay Stadium, Reno, NV | Toledo | Toledo |
| UNLV | Idaho | Kibbie Dome, Moscow, ID | Idaho | Idaho |
| North Texas | SMU | Gerald J. Ford Stadium, Dallas, TX | SMU | SMU |
| Southern | Southern Mississippi | M. M. Roberts Stadium, Hattiesburg, MS | USM | USM |
| South Carolina | Missouri | Memorial Stadium/Faurot Field, Columbia, MO | SC | South Carolina |
| Nicholls | Texas A&M | Kyle Field, College Station, TX | A&M | TAMU |
| #7 Oklahoma | #2 Ohio State | Ohio Stadium, Columbus, OH | Ohio St | Ohio State |
| Chattanooga | #13 LSU | Tiger Stadium , Baton Rouge, LA | LSU | LSU |
| #15 Georgia | Notre Dame | Notre Dame Stadium, Notre Dame, IN | ND | UGA |
| Northern Colorado | #17 Florida | Ben Hill Griffin Stadium, Gainesville, FL | Florida | Florida |
| Mississippi State | Louisiana Tech | Joe Aillet Stadium, Ruston, LA | Miss St | Miss St |
| Alcorn State | Florida Intl | FIU Stadium, Miami, FL | FIU | FIU |
| Montana | #8 Washington | Husky Stadium, Seattle, WA | Wash | Washington |
| Rice | UTEP | Sun Bowl, El Paso, TX | Rice | Rice |
| New Mexico State | New Mexico | Dreamstyle Stadium, Albuquerque, NM | New Mex | NM |
| Memphis | UCF | Bright House Networks Stadium, Orlando, FL | Memphis | Memphis |
| UT San Antonio | Baylor | McLane Stadium, Waco, TX | UTSA | UTSA |
| Western Kentucky | Illinois | Memorial Stadium , Champaign, IL | WKU | Illinois |
| #14 Stanford | #4 USC | Los Angeles Memorial Coliseum, Los Angeles, CA | USC | Stanford |
| Minnesota | Oregon State | Reser Stadium, Corvallis, OR | Minnesota | Minnesota |
| Utah | BYU | LaVell Edwards Stadium, Provo, UT | Utah | Utah |
| Boise State | #24 Washington St | Martin Stadium, Pullman, WA | Boise | Wazzu |
| Houston | Arizona | Arizona Stadium, Tucson, AZ | Arizona | Houston |
| San Diego State | Arizona State | Sun Devil Stadium, Tempe, AZ | Arizona St | ASU |
| Gameday Guest Picker (Columbus) | Archie Griffin | Nick Swisher |
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