Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 4 Picks.
| Away | Home | Location | Cecil | Joe |
| Philadelphia | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
| Tennessee | Atlanta | Mercedes-Benz Stadium, Atlanta | Titans | Falcons |
| New England | Buffalo | New Era Field, Buffalo | Patriots | Patriots |
| Kansas City | Detroit | Ford Field, Detroit | Chiefs | Chiefs |
| Oakland | Indianapolis | Lucas Oil Stadium, Indianapolis | Colts | Colts |
| Los Angeles Chargers | Miami | Hard Rock Stadium, Miami Gardens | Chargers | Chargers |
| Washington | New York Giants | MetLife Stadium, East Rutherford | Giants | Giants |
| Cleveland | Baltimore | M&T Bank Stadium, Baltimore | Ravens | Ravens |
| Carolina | Houston | NRG Stadium, Houston | Texans | Texans |
| Tampa Bay | Los Angeles Rams | Los Angeles Memorial Coliseum, Los Angeles | Rams | Rams |
| Seattle | Arizona | State Farm Stadium, Glendale | Seahawks | Seahawks |
| Minnesota | Chicago | Soldier Field, Chicago | Bears | Bears |
| Jacksonville | Denver | Empower Field at Mile High, Denver | Jaguars | Jaguars |
| Dallas | New Orleans | Mercedes-Benz Superdome, New Orleans | Cowboys | Cowboys |
| Cincinnati | Pittsburgh | Heinz Field, Pittsburgh | Steelers | Steelers |
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