Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 2 Picks.
| Away | Home | Location | Cecil | Joe |
| Tampa Bay | Carolina | Bank of America Stadium, Charlotte | Panthers | Carolina |
| San Francisco | Cincinnati | Paul Brown Stadium, Cincinnati | Bengals | 49ers |
| Los Angeles Chargers | Detroit | Ford Field, Detroit | Chargers | Chargers |
| Minnesota | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
| Indianapolis | Tennessee | Nissan Stadium, Nashville | Titans | Titans |
| New England | Miami | Hard Rock Stadium, Miami Gardens | Pats | Pats |
| Buffalo | New York Giants | MetLife Stadium, East Rutherford | Bills | Giants |
| Seattle | Pittsburgh | Heinz Field, Pittsburgh | Seahawks | Steelers |
| Dallas | Washington | FedEx Field, Landover | Cowboys | Cowboys |
| Arizona | Baltimore | M&T Bank Stadium, Baltimore | Ravens | Ravens |
| Jacksonville | Houston | NRG Stadium, Houston | Texans | Texans |
| Kansas City | Oakland | RingCentral Coliseum, Oakland | Chiefs | Chiefs |
| Chicago | Denver | Empower Field at Mile High, Denver | Bears | Bears |
| New Orleans | Los Angeles Rams | Los Angeles Memorial Coliseum, Los Angeles | Saints | Rams |
| Philadelphia | Atlanta | Mercedes-Benz Stadium, Atlanta | Eagles | Falcons |
| Cleveland | New York | MetLife Stadium, East Rutherford | Browns | Browns |
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