Joe DiTullio and Rob Doerger make college football picks for week 12, which includes all games involving FBS teams. There have been plenty of touchdowns, sacks and big plays with more to come. Here are the picks for the week:
| Away | Home | Location | Rob | Joe |
| Central Michigan | Kent State | Dix Stadium, Kent, OH | C. Mich | CMU |
| Ohio | Akron | InfoCision Stadium, Akron, OH | Ohio | Ohio |
| Eastern Michigan | Miami (OH) | Yager Stadium, Oxford, OH | Miami (OH) | Miami |
| Western Michigan | Northern Illinois | Huskie Stadium, DeKalb, IL | NIU | NIU |
| Toledo | Bowling Green | Doyt Perry Stadium, Bowling Green, OH | Toledo | Toledo |
| Buffalo | Ball State | Scheumann Stadium, Muncie, IN | Ball St | Ball St |
| Tulsa | South Florida | Raymond James Stadium, Tampa, FL | USF | USF |
| Middle Tennessee | Western Kentucky | L.T. Smith Stadium, Bowling Green, KY | WKU | WKU |
| UNLV | New Mexico | Dreamstyle Stadium, Albuquerque, NM | New Mex | NM |
| Mercer | #2 Alabama | Bryant-Denny Stadium, Tuscaloosa, AL | Bama | Bama |
| #6 TCU | Texas Tech | Jones AT&T Stadium, Lubbock, TX | TCU | TCU |
| Virginia | #7 Miami | Hard Rock Stadium, Miami, FL | Miami | Miami |
| Michigan | #8 Wisconsin | Camp Randall Stadium, Madison, WI | Wisconsin | Wisconsin |
| Louisiana Monroe | #10 Auburn | Jordan-Hare Stadium, Auburn, AL | Auburn | Auburn |
| #16 Mississippi State | Arkansas | Razorback Stadium, Fayetteville, AR | Miss State | Miss State |
| #18 UCF | Temple | Lincoln Financial Field, Philadelphia, PA | UCF | UCF |
| SMU | #22 Memphis | Liberty Bowl Memorial Stadium, Memphis, TN | Memphis | Memphis |
| Minnesota | #25 Northwestern | Ryan Field, Evanston, IL | NW | NW |
| Cincinnati | East Carolina | Dowdy-Ficklen Stadium, Greenville, NC | ECTC | UC |
| Texas | West Virginia | Milan Puskar Stadium, Morgantown, WV | WVU | WVU |
| Rutgers | Indiana | Memorial Stadium , Bloomington, IN | Indiana | IU |
| Delaware State | Florida State | Doak Campbell Stadium, Tallahassee, FL | FSU | FSU |
| The Citadel | #4 Clemson | Memorial Stadium , Clemson, SC | Clemson | Clemson |
| Pittsburgh | #17 Virginia Tech | Lane Stadium, Blacksburg, VA | VT | VT |
| Rice | Old Dominion | S.B. Ballard Stadium, Norfolk, VA | Old Dom | ODU |
| Fresno State | Wyoming | War Memorial Stadium , Laramie, WY | Wyoming | Wyoming |
| #21 Iowa State | Baylor | McLane Stadium, Waco, TX | Iowa St | ISU |
| Arizona State | Oregon State | Reser Stadium, Corvallis, OR | Arizona St | ASU |
| Charlotte | Southern Mississippi | M. M. Roberts Stadium, Hattiesburg, MS | So Miss | USM |
| Louisiana Tech | UTEP | Sun Bowl, El Paso, TX | La Tech | La Tech |
| Western Carolina | North Carolina | Kenan Stadium, Chapel Hill, NC | UNC-CH | UNC |
| Hawai’i | Utah State | Romney Stadium, Logan, UT | Utah St | Utah St. |
| UMass | BYU | LaVell Edwards Stadium, Provo, UT | BYU | BYU |
| Texas State | Arkansas State | Centennial Bank Stadium, Jonesboro, AR | Ark St | Ark State |
| South Alabama | Georgia Southern | Allen E. Paulson Stadium, Statesboro, GA | USA | USA |
| Kentucky | #1 Georgia | Sanford Stadium, Athens, GA | Georgia | Georgia |
| Navy | #3 Notre Dame | Notre Dame Stadium, Notre Dame, IN | ND | ND |
| #5 Oklahoma | Kansas | Memorial Stadium , Lawrence, KS | Oklahoma | Oklahoma |
| Illinois | #13 Ohio State | Ohio Stadium, Columbus, OH | OSU | OSU |
| Margin of victory | 52 | 43 | ||
| Kansas State | #15 Oklahoma State | Boone Pickens Stadium, Stillwater, OK | OK State | Ok State |
| Purdue | #20 Iowa | Kinnick Stadium, Iowa City, IA | Iowa | Iowa |
| San Jose State | Colorado State | CSU Stadium, Fort Collins, CO | Col St | Col St |
| Syracuse | Louisville | Papa John’s Cardinal Stadium, Louisville, KY | Louisville | Louisville |
| Georgia Tech | Duke | Wallace Wade Stadium, Durham, NC | GT | GT |
| Maryland | #12 Michigan State | Spartan Stadium , East Lansing, MI | Mich St | MSU |
| Nebraska | #14 Penn State | Beaver Stadium, University Park, PA | Penn St | PSU |
| Wofford | South Carolina | Williams-Brice Stadium, Columbia, SC | SC | SC |
| UAB | Florida | Ben Hill Griffin Stadium, Gainesville, FL | UAB | UF |
| Houston | Tulane | Yulman Stadium, New Orleans, LA | Houston | Houston |
| Coastal Carolina | Idaho | Kibbie Dome, Moscow, ID | Idaho | Idaho |
| New Mexico State | Louisiana | Cajun Field, Lafayette, LA | ULL | ULL |
| Army | North Texas | Apogee Stadium, Denton, TX | Army | Army |
| #24 LSU | Tennessee | Neyland Stadium, Knoxville, TN | LSU | LSU |
| Arizona | Oregon | Autzen Stadium, Eugene, OR | Arizona | Arizona |
| Texas A&M | Ole Miss | Vaught-Hemingway Stadium, Oxford, MS | Ole Miss | TAMU |
| Boston College | Connecticut | Fenway Park, Boston, MA | BC | BC |
| Marshall | UT San Antonio | Alamodome, San Antonio, TX | Marshall | Marshall |
| Florida Intl | Florida Atlantic | FAU Football Stadium, Boca Raton, FL | FAU | FAU |
| #23 NC State | Wake Forest | BB&T Field, Winston-salem, NC | Wake | NC State |
| Missouri | Vanderbilt | Vanderbilt Stadium, Nashville, TN | Mizzou | Mizzou |
| UCLA | #11 USC | Los Angeles Memorial Coliseum, Los Angeles, CA | USC | USC |
| California | Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| Air Force | Boise State | Albertsons Stadium, Boise, ID | Boise | Boise |
| Utah | #9 Washington | Husky Stadium, Seattle, WA | Washington | Washington |
| Nevada | San Diego State | SDCCU Stadium, San Diego, CA | SDSU | SDSU |
| Gameday Guest Picker (Madison, WI) | Ron Dayne | Ron Dayne |
