Rob Doerger and Joe DiTullio make their picks for every FBS college football game this weekend.
| Away | Home | Location | Rob | Joe |
| Miami | Virginia Tech | Lane Stadium, Blacksburg, VA | VT | Miami |
| Troy | South Alabama | Ladd-Peebles Stadium, Mobile, AL | Troy | South Alabama |
| BYU | #14 Boise State | Albertsons Stadium, Boise, ID | Boise | Boise |
| South Florida | Temple | Lincoln Financial Field, Philadelphia, PA | USF | USF |
| San José State | San Diego State | Qualcomm Stadium, San Diego, CA | SDSU | SDSU |
| Oregon | California | Memorial Stadium , Berkeley, CA | Cal | Cal |
| North Texas | Army | Michie Stadium, West Point, NY | Army | Army |
| Massachusetts | South Carolina | Williams-Brice Stadium, Columbia, SC | Umass | So. Car |
| UCF | Connecticut | Rentschler Field, East Hartford, CT | UCF | UCONN |
| Central Michigan | Toledo | Glass Bowl, Toledo, OH | Toledo | Toldeo |
| Miami (OH) | Bowling Green | Doyt Perry Stadium, Bowling Green, OH | Bowling Green | BG |
| Indiana | Northwestern | Ryan Field, Evanston, IL | NW | NW |
| #10 Wisconsin | Iowa | Kinnick Stadium, Iowa City, IA | Buzzcuts | Wisconsin |
| NC State | #7 Louisville | Papa John’s Cardinal Stadium, Louisville, KY | Louisville | Louisville |
| Oklahoma State | Kansas | Memorial Stadium , Lawrence, KS | OK St | Ok St |
| Texas | Kansas State | Bill Snyder Family Stadium, Manhattan, KS | Kansas St | Texas |
| Rutgers | Minnesota | TCF Bank Stadium, Minneapolis, MN | Minnesota | Minnesota |
| Syracuse | Boston College | Alumni Stadium , Chestnut Hill, MA | Syracuse | Syracuse |
| Ohio | Kent State | Dix Stadium, Kent, OH | Ohio | Ohio |
| Hawai’i | Air Force | Falcon Stadium, Usaf Academy, CO | AFA | AF |
| Akron | Ball State | Scheumann Stadium, Muncie, IN | Akron | Akron |
| Colorado | Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| #22 North Carolina | Virginia | Scott Stadium, Charlottesville, VA | UNC | UNC |
| Memphis | #24 Navy | Navy-Marine Corps Memorial Stadium, Annapolis, MD | Navy | Navy |
| Illinois | #3 Michigan | Michigan Stadium, Ann Arbor, MI | Michigan | Michigan |
| Margin of Victory | 46 | 34 | ||
| Purdue | #8 Nebraska | Memorial Stadium , Lincoln, NE | Nebraska | Nebraska |
| TCU | #12 West Virginia | Milan Puskar Stadium, Morgantown, WV | WVU | WVU |
| Idaho | Appalachian State | Kidd Brewer Stadium, Boone, NC | App St | App ST |
| Tennessee-Martin | Georgia State | Georgia Dome, Atlanta, GA | GSU | GSU |
| Buffalo | Northern Illinois | Huskie Stadium, DeKalb, IL | NIU | Buffalo |
| #6 Texas A&M | #1 Alabama | Bryant-Denny Stadium, Tuscaloosa, AL | Alabama | TAMU |
| Eastern Michigan | #20 Western Michigan | Waldo Stadium, Kalamazoo, MI | WMU | WMU |
| Prairie View | Rice | Rice Stadium, Houston, TX | Rice | RICE |
| Tulane | Tulsa | Chapman Stadium, Tulsa, OK | Tulsa | Tulsa |
| #19 Utah | UCLA | Rose Bowl, Pasadena, CA | UCLA | UCLA |
| Middle Tennessee | Missouri | Memorial Stadium/Faurot Field, Columbia, MO | Mizzou | Mizzou |
| Colorado State | UNLV | Sam Boyd Stadium, Las Vegas, NV | UNLV | UNLV |
| Charlotte | Marshall | Joan C. Edwards Stadium, Huntington, WV | Marshall | Marshall |
| #17 Arkansas | #21 Auburn | Jordan-Hare Stadium, Auburn, AL | Auburn | Auburn |
| Oregon State | #5 Washington | Husky Stadium, Seattle, WA | Washington | Washington |
| Louisiana Tech | Florida Intl | FIU Stadium, Miami, FL | LT | LT |
| Old Dominion | Western Kentucky | L.T. Smith Stadium, Bowling Green, KY | WKU | WKU |
| UTEP | Texas San Antonio | Alamodome, San Antonio, TX | UTSA | UTSA |
| East Carolina | Cincinnati | Nippert Stadium, Cincinnati, OH | Cincy | Cincy |
| #11 Houston | SMU | Gerald J. Ford Stadium, Dallas, TX | Houston | Houston |
| Louisiana Lafayette | Texas State | Bobcat Stadium , San Marcos, TX | ULL | ULL |
| Michigan State | Maryland | Maryland Stadium, College Park, MD | Mich St | MSU |
| Mississippi State | Kentucky | Commonwealth Stadium, Lexington, KY | Kentucky | UK |
| Tennessee State | Vanderbilt | Vanderbilt Stadium, Nashville, TN | Vandy | Vanderbilt |
| Georgia Southern | New Mexico State | Aggie Memorial Stadium, Las Cruces, NM | GSU | GSU |
| #2 Ohio State | Penn State | Beaver Stadium, University Park, PA | OSU | OSU |
| #16 Oklahoma | Texas Tech | Jones AT&T Stadium, Lubbock, TX | OK | Oklahoma |
| #23 Ole Miss | #25 LSU | Tiger Stadium , Baton Rouge, LA | LSU | Ole Miss |
| Louisiana Monroe | New Mexico | University Stadium , Albuquerque, NM | New Mexico | NM |
| Washington State | Arizona State | Sun Devil Stadium, Tempe, AZ | Wash St | WAZZU |
| Fresno State | Utah State | Romney Stadium, Logan, UT | Utah St | Utah St |
| Wyoming | Nevada | Mackay Stadium, Reno, NV | Wyoming | Wyoming |
| Gameday Guest Picker (Tuscaloosa) | Kenny Chesney | Shaun Alexander |