Rob Doerger and Joe DiTullio make their picks for every FBS college football game this weekend.
| Away | Home | Location | Rob | Joe |
| Miami | Virginia Tech | Lane Stadium, Blacksburg, VA | VT | Miami |
| Troy | South Alabama | Ladd-Peebles Stadium, Mobile, AL | Troy | South Alabama |
| BYU | #14 Boise State | Albertsons Stadium, Boise, ID | Boise | Boise |
| South Florida | Temple | Lincoln Financial Field, Philadelphia, PA | USF | USF |
| San José State | San Diego State | Qualcomm Stadium, San Diego, CA | SDSU | SDSU |
| Oregon | California | Memorial Stadium , Berkeley, CA | Cal | Cal |
| North Texas | Army | Michie Stadium, West Point, NY | Army | Army |
| Massachusetts | South Carolina | Williams-Brice Stadium, Columbia, SC | Umass | So. Car |
| UCF | Connecticut | Rentschler Field, East Hartford, CT | UCF | UCONN |
| Central Michigan | Toledo | Glass Bowl, Toledo, OH | Toledo | Toldeo |
| Miami (OH) | Bowling Green | Doyt Perry Stadium, Bowling Green, OH | Bowling Green | BG |
| Indiana | Northwestern | Ryan Field, Evanston, IL | NW | NW |
| #10 Wisconsin | Iowa | Kinnick Stadium, Iowa City, IA | Buzzcuts | Wisconsin |
| NC State | #7 Louisville | Papa John’s Cardinal Stadium, Louisville, KY | Louisville | Louisville |
| Oklahoma State | Kansas | Memorial Stadium , Lawrence, KS | OK St | Ok St |
| Texas | Kansas State | Bill Snyder Family Stadium, Manhattan, KS | Kansas St | Texas |
| Rutgers | Minnesota | TCF Bank Stadium, Minneapolis, MN | Minnesota | Minnesota |
| Syracuse | Boston College | Alumni Stadium , Chestnut Hill, MA | Syracuse | Syracuse |
| Ohio | Kent State | Dix Stadium, Kent, OH | Ohio | Ohio |
| Hawai’i | Air Force | Falcon Stadium, Usaf Academy, CO | AFA | AF |
| Akron | Ball State | Scheumann Stadium, Muncie, IN | Akron | Akron |
| Colorado | Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| #22 North Carolina | Virginia | Scott Stadium, Charlottesville, VA | UNC | UNC |
| Memphis | #24 Navy | Navy-Marine Corps Memorial Stadium, Annapolis, MD | Navy | Navy |
| Illinois | #3 Michigan | Michigan Stadium, Ann Arbor, MI | Michigan | Michigan |
| Margin of Victory | 46 | 34 | ||
| Purdue | #8 Nebraska | Memorial Stadium , Lincoln, NE | Nebraska | Nebraska |
| TCU | #12 West Virginia | Milan Puskar Stadium, Morgantown, WV | WVU | WVU |
| Idaho | Appalachian State | Kidd Brewer Stadium, Boone, NC | App St | App ST |
| Tennessee-Martin | Georgia State | Georgia Dome, Atlanta, GA | GSU | GSU |
| Buffalo | Northern Illinois | Huskie Stadium, DeKalb, IL | NIU | Buffalo |
| #6 Texas A&M | #1 Alabama | Bryant-Denny Stadium, Tuscaloosa, AL | Alabama | TAMU |
| Eastern Michigan | #20 Western Michigan | Waldo Stadium, Kalamazoo, MI | WMU | WMU |
| Prairie View | Rice | Rice Stadium, Houston, TX | Rice | RICE |
| Tulane | Tulsa | Chapman Stadium, Tulsa, OK | Tulsa | Tulsa |
| #19 Utah | UCLA | Rose Bowl, Pasadena, CA | UCLA | UCLA |
| Middle Tennessee | Missouri | Memorial Stadium/Faurot Field, Columbia, MO | Mizzou | Mizzou |
| Colorado State | UNLV | Sam Boyd Stadium, Las Vegas, NV | UNLV | UNLV |
| Charlotte | Marshall | Joan C. Edwards Stadium, Huntington, WV | Marshall | Marshall |
| #17 Arkansas | #21 Auburn | Jordan-Hare Stadium, Auburn, AL | Auburn | Auburn |
| Oregon State | #5 Washington | Husky Stadium, Seattle, WA | Washington | Washington |
| Louisiana Tech | Florida Intl | FIU Stadium, Miami, FL | LT | LT |
| Old Dominion | Western Kentucky | L.T. Smith Stadium, Bowling Green, KY | WKU | WKU |
| UTEP | Texas San Antonio | Alamodome, San Antonio, TX | UTSA | UTSA |
| East Carolina | Cincinnati | Nippert Stadium, Cincinnati, OH | Cincy | Cincy |
| #11 Houston | SMU | Gerald J. Ford Stadium, Dallas, TX | Houston | Houston |
| Louisiana Lafayette | Texas State | Bobcat Stadium , San Marcos, TX | ULL | ULL |
| Michigan State | Maryland | Maryland Stadium, College Park, MD | Mich St | MSU |
| Mississippi State | Kentucky | Commonwealth Stadium, Lexington, KY | Kentucky | UK |
| Tennessee State | Vanderbilt | Vanderbilt Stadium, Nashville, TN | Vandy | Vanderbilt |
| Georgia Southern | New Mexico State | Aggie Memorial Stadium, Las Cruces, NM | GSU | GSU |
| #2 Ohio State | Penn State | Beaver Stadium, University Park, PA | OSU | OSU |
| #16 Oklahoma | Texas Tech | Jones AT&T Stadium, Lubbock, TX | OK | Oklahoma |
| #23 Ole Miss | #25 LSU | Tiger Stadium , Baton Rouge, LA | LSU | Ole Miss |
| Louisiana Monroe | New Mexico | University Stadium , Albuquerque, NM | New Mexico | NM |
| Washington State | Arizona State | Sun Devil Stadium, Tempe, AZ | Wash St | WAZZU |
| Fresno State | Utah State | Romney Stadium, Logan, UT | Utah St | Utah St |
| Wyoming | Nevada | Mackay Stadium, Reno, NV | Wyoming | Wyoming |
| Gameday Guest Picker (Tuscaloosa) | Kenny Chesney | Shaun Alexander |
Players must be 21 years of age or older or reach the minimum age for gambling in their respective state and located in jurisdictions where online gambling is legal. Please play responsibly. Bet with your head, not over it. If you or someone you know has a gambling problem, and wants help, call or visit: (a) the Council on Compulsive Gambling of New Jersey at 1-800-Gambler or www.800gambler.org; or (b) Gamblers Anonymous at 855-2-CALL-GA or www.gamblersanonymous.org.
