Rob Doerger and Joe DiTullio (DiTullio and Doerger College Sports Show) make their week 10 college football picks.
| Away | Home | Location | Rob | Joe |
| Bowling Green | Northern Illinois | Huskie Stadium, DeKalb, IL | N. Illinois | NIU |
| #17 Western Michigan | Ball State | Scheumann Stadium, Muncie, IN | WMU | WMU |
| Toledo | Akron | InfoCision Stadium, Akron, OH | Akron | Toledo |
| Buffalo | Ohio | Peden Stadium, Athens, OH | Ohio | Ohio |
| #12 Oklahoma | Iowa State | Jack Trice Stadium, Ames, IA | OK | OU |
| Arkansas State | Georgia State | Georgia Dome, Atlanta, GA | Ark St | Ark St |
| UCLA | #21 Colorado | Folsom Field, Boulder, CO | Colorado | Colorado |
| Central Michigan | Miami (OH) | Yager Stadium, Oxford, OH | CMU | CMU |
| Temple | Connecticut | Rentschler Field, East Hartford, CT | Temple | UCONN |
| San José State | #24 Boise State | Albertsons Stadium, Boise, ID | Boise | Boise |
| Navy | Notre Dame | EverBank Field, Jacksonville, FL | Notre Dame | ND |
| Air Force | Army | Michie Stadium, West Point, NY | Army | AF |
| Georgia Southern | Ole Miss | Vaught-Hemingway Stadium, Oxford, MS | Ole Miss | Ole Miss |
| #7 Texas A&M | Mississippi State | Davis Wade Stadium, Starkville, MS | A&M | TAMU |
| Vanderbilt | #11 Auburn | Jordan-Hare Stadium, Auburn, AL | Auburn | Aburn |
| #5 Louisville | Boston College | Alumni Stadium , Chestnut Hill, MA | Louisville | Louisvile |
| Texas | Texas Tech | Jones AT&T Stadium, Lubbock, TX | TTU | TTU |
| Indiana | Rutgers | High Point Solutions Stadium, Piscataway, NJ | Indiana | IU |
| Michigan State | Illinois | Memorial Stadium , Champaign, IL | MSU | MSU |
| #8 Wisconsin | Northwestern | Ryan Field, Evanston, IL | Wisconsin | Wisconsin |
| Georgia Tech | #18 North Carolina | Kenan Stadium, Chapel Hill, NC | UNC | UNC |
| Pittsburgh | Miami | Hard Rock Stadium, Miami, FL | Pitt | Pitt |
| Texas San Antonio | Middle Tennessee | Floyd Stadium, Murfreesboro, TN | MTSU | MTSU |
| Virginia | Wake Forest | BB&T Field, Winston-salem, NC | Wake | Wake |
| Maryland | #2 Michigan | Michigan Stadium, Ann Arbor, MI | Michigan | Michigan |
| Purdue | Minnesota | TCF Bank Stadium, Minneapolis, MN | Minnesota | Minnesota |
| Texas State | Appalachian State | Kidd Brewer Stadium, Boone, NC | App St | App St |
| #22 Oklahoma State | Kansas State | Bill Snyder Family Stadium, Manhattan, KS | Kansas St | OK St |
| Syracuse | #3 Clemson | Memorial Stadium , Clemson, SC | Clemson | Clemson |
| #23 Virginia Tech | Duke | Wallace Wade Stadium, Durham, NC | VT | VT |
| Florida Atlantic | Rice | Rice Stadium, Houston, TX | FAU | FAU |
| Charlotte | Southern Mississippi | M. M. Roberts Stadium, Hattiesburg, MS | S. Miss | So Miss |
| Oregon State | Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| TCU | #13 Baylor | McLane Stadium, Waco, TX | Baylor | Baylor |
| Fresno State | Colorado State | Hughes Stadium , Fort Collins, CO | Col St | CSU |
| BYU | Cincinnati | Nippert Stadium, Cincinnati, OH | BYU | BYU |
| Massachusetts | Troy | Veterans Memorial Stadium , Troy, AL | Troy | Troy |
| #10 Florida | Arkansas | Razorback Stadium, Fayetteville, AR | Florida | Florida |
| Missouri | South Carolina | Williams-Brice Stadium, Columbia, SC | SC | SC |
| Tennessee Tech | Tennessee | Neyland Stadium, Knoxville, TN | Tennesse | Tennessee |
| Arizona | #25 Washington State | Martin Stadium, Pullman, WA | Wazzu | Wazzu |
| Memphis | SMU | Gerald J. Ford Stadium, Dallas, TX | SMU | SMU |
| Idaho | Louisiana Lafayette | Cajun Field, Lafayette, LA | ULL | ULL |
| South Alabama | Louisiana Monroe | Malone Stadium, Monroe, LA | USA | USA |
| Tulane | UCF | Bright House Networks Stadium, Orlando, FL | UCF | UCF |
| Florida Intl | Western Kentucky | L.T. Smith Stadium, Bowling Green, KY | WKU | WKU |
| Louisiana Tech | North Texas | Apogee Stadium, Denton, TX | LT | La Tech |
| Marshall | Old Dominion | S.B. Ballard Stadium, Norfolk, VA | Old Dom | Marshall |
| #19 Florida State | NC State | Carter-Finley Stadium, Raleigh, NC | FSU | FSU |
| Hawai’i | San Diego State | Qualcomm Stadium, San Diego, CA | San Diego St | SDSU |
| Oregon | USC | Los Angeles Memorial Coliseum, Los Angeles, CA | USC | USC |
| Kansas | #14 West Virginia | Milan Puskar Stadium, Morgantown, WV | WVU | WVU |
| Margin of Victory | 44 | 35 | ||
| Iowa | #20 Penn State | Beaver Stadium, University Park, PA | Penn St | Penn St |
| Georgia | Kentucky | Commonwealth Stadium, Lexington, KY | Kentucky | UK |
| #1 Alabama | #15 LSU | Tiger Stadium , Baton Rouge, LA | LSU | LSU |
| Houston Baptist | UTEP | Sun Bowl, El Paso, TX | UTEP | UTEP |
| East Carolina | Tulsa | Chapman Stadium, Tulsa, OK | Tulsa | Tulsa |
| #9 Nebraska | #6 Ohio State | Ohio Stadium, Columbus, OH | Nebraska | OSU |
| Nevada | New Mexico | University Stadium , Albuquerque, NM | New Mexico | NM |
| Utah State | Wyoming | War Memorial Stadium , Laramie, WY | Wyoming | Wyoming |
| #4 Washington | California | Memorial Stadium , Berkeley, CA | Washington | Washington |
| Celebrity Guest Picker (Baton Rouge) | Ryan Clark | Ryen Russillo |