The college basketball season has started! There are plenty of big games that will be picked this year. Here are college basketball picks week of December 16.
Note: These are moneyline picks. There will be a new picks article every week.
| Away | Home | Joe |
| Western Carolina | Tennessee | Tennessee |
| George Mason | Duke | Duke |
| North Carolina | Florida | Florida |
| Southern | Ole Miss | Ole Miss |
| Michigan Stae | Oakland | MSU |
| UNLV | Dayton | Dayton |
| Clemson | South Carolina | Clemson |
| Georgia State | Auburn | Auburn |
| Prairie View A&M | UCLA | UCLA |
| Xavier | UConn | UConn |
| Memphis | Virginia | Memphis |
| Toledo | Houston | Houston |
| Alabama | North Dakota | Alabama |
| Butler | Marquette | Marquette |
| Nicholls | Gonzaga | Gonzaga |
| Oklahoma | Michigan | Michigan |
| Houston Christian | Texas A&M | Texas A&M |
| Cincinnati | Dayton | Cincinnati |
| Marquette | Xavier | Marquette |
| Duke | Georgia Tech | Duke |
| North Florida | Florida | Florida |
| UConn | Butler | UConn |
| Mississippi State | Memphis | Mississippi State |
| Texas A&M CC | Houston | Houston |
| FAU | Michigan State | Michigan State |
| Wake Forest | Clemson | Clemson |
| UCLA | UNC | UNC |
| Purdue | Auburn | Auburn |
| Queens | Ole Miss | Ole Miss |
| Ohio State | Kentucky | Kentucky |
| Oregon | Stanford | Oregon |
| Bucknell | Gonzaga | Gonzaga |
| California | San Diego State | SDSU |
| Morgan State | Iowa State | Iowa State |
| Kent State | Alabama | Alabama |
| Central Arkansas | Oklahoma | Oklahoma |
| Purdue Fort Wayne | Michigan | Michigan |
| Brown | Kansas | Kansas |
| Grambling | Cincinnati | Cincinnati |
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