Joe DiTullio and Cecil Walker (Personalities on the Third and the Don Football Show) make their picks for the week four match-ups.
| Away Team | Home Team | Joe | Cecil |
| Miami Dolphins | Cincinnati Bengals | Bengals | Bengals |
| Indianapolis Colts | Jacksonville Jaguars | Colts | Jags |
| Tennessee Titans | Houston Texans | Texans | Texans |
| Cleveland Browns | Washington Redskins | Browns (Upset Pick) | Redskins |
| Seattle Seahawks | New York Jets | Seahawks | Jets |
| Buffalo Bills | New England Patriots | Patriots | Patriots |
| Carolina Panthers | Atlanta Falcons | Panthers | Panthers |
| Oakland Raiders | Baltimore Ravens | Ravens | Ravens |
| Detroit Lions | Chicago Bears | Lions | Lions |
| Denver Broncos | Tampa Bay Buccaneers | Broncos | Broncos |
| Dallas Cowboys | San Francisco 49ers | Cowboys | Cowboys |
| St. Louis Rams | Arizona Cardinals | Cardinals | Cardinals |
| New Orleans Saints | San Diego Chargers | Chargers | Chargers |
| Kansas City Chiefs | Pittsburgh Steelers | Steelers | Steelers |
| New York Giants | Minnesota Vikings | Vikings | Vikings |
| Season Total | 30 | 28 |
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