NFL Week 6 is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are the NFL week 6 picks against the spread. (Spreads are from Tallysight as of Tuesday morning)
Last Week: 9-5
Season: 40-35-3
San Francisco 49ers (-3) at Seattle Seahawks
Seattle just lost to the Giants and their defense has some issues. The 49ers can exploit the defense, even on a short week.
Pick: 49ers
Jacksonville Jaguars at Chicago Bears (-2)
Jacksonville got in the win column last week against the Colts. The Bears have played good defense this season and should be able to make the Jaguars stagnant on offense like they were the first few weeks of the season.
Pick: Bears
Tampa Bay Buccaneers (-2.5) at New Orleans Saints
New Orleans started the year well, but have slowed down significantly. They will be on a short week for this game. Tampa Bay has too many weapons and the Saints may not be able to catch up offensively.
Pick: Buccaneers
Arizona Cardinals at Green Bay Packers (-5)
Green Bay got things back on track in week 5 with a win over the Rams. There is still some sloppy play on their end. Arizona’s upset over San Francisco can give them confidence enough to keep this close.
Pick: Cardinals
Indianapolis Colts (-1) at Tennessee Titans
Tennessee is coming off a bye, but they have issues finding consistency on offense. The turnovers could come back to get them in this game. Indianapolis can find success whether Anthony Richardson or Joe Flacco is at quarterback.
Pick: Colts
Cleveland Browns at Philadelphia Eagles (-8.5)
Philadelphia is also coming off a bye this week. Cleveland has a disaster of an offense and the Eagles’ defense can play better in this game. They can win and cover at home.
Pick: Eagles
Houston Texans (-7) at New England Patriots
New England has reports of locker room issues and they haven’t played good football since week 1. Houston hasn’t played their best football, but they are undefeated. This could be a week when they play a complete game.
Pick: Texans
Washington Commanders at Baltimore Ravens (-6.5)
Washington’s offense is on fire with Jayden Daniels leading the way. Baltimore’s offense has had success this season, but the defense has given up some big games. The Ravens can win, but the Commanders can keep it close.
Pick: Commanders
Los Angeles Chargers (-3) at Denver Broncos
The Chargers were on bye in week five giving them ample time to prep. Denver has some offensive limitations with Bo Nix at quarterback and the Chargers should be able to outscore them.
Pick: Chargers
Pittsburgh Steelers (-3) at Las Vegas Raiders
Las Vegas has a quarterback issue and at least one player who wants a new team. The Steelers’ defense can lead them to a win on the road.
Pick: Steelers
Atlanta Falcons (-6) at Carolina Panthers
Inserting Andy Dalton into the lineup saw immediate results, but those are wearing off. Atlanta has extra time to prepare for this game and Kirk Cousins is playing well.
Pick: Falcons
Detroit Lions (-3.5) at Dallas Cowboys
The Lions are coming off a bye and run the ball well. Coincidentally, the Cowboys struggle against the run. Detroit can wear them down and win the game.
Pick: Lions
Cincinnati Bengals (-3.5) at New York Giants
The Bengals’ defense has not been good, but their offense has been on fire. A few key turnovers against the Giants can help them win and cover on the road.
Pick: Bengals
Buffalo Bills (-2.5) at New York Jets
Buffalo just had a tough game against the Texans, but should be able to rebound. New York made a head coaching change, which may give them a temporary lift, but it will be hard to keep up with the Bills.
Pick: Bills
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