Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 6 Picks.
| Away | Home | Location | Cecil | Joe |
| New York Giants | New England | Gillette Stadium, Foxboro | Patriots | Patriots |
| Carolina | Tampa Bay | Tottenham Hotspur Stadium, London | Panthers | Bucs |
| Seattle | Cleveland | FirstEnergy Stadium, Cleveland | Seahawks | Seahawks |
| Houston | Kansas City | Arrowhead Stadium, Kansas City | Texans | Chiefs |
| Washington | Miami | Hard Rock Stadium, Miami Gardens | Redskins | Redskins |
| Philadelphia | Minnesota | U.S. Bank Stadium, Minneapolis | Vikings | Eagles |
| New Orleans | Jacksonville | TIAA Bank Field, Jacksonville | Saints | Saints |
| Cincinnati | Baltimore | M&T Bank Stadium, Baltimore | Ravens | Ravens |
| San Francisco | Los Angeles Rams | Los Angeles Memorial Coliseum, Los Angeles | Rams | Rams |
| Atlanta | Arizona | State Farm Stadium, Glendale | Falcons | Falcons |
| Tennessee | Denver | Empower Field at Mile High, Denver | Broncos | Titans |
| Dallas | New York Jets | MetLife Stadium, East Rutherford | Cowboys | Cowboys |
| Pittsburgh | Los Angeles Chargers | Dignity Health Sports Park, Carson | Chargers | Chargers |
| Detroit | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
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