Home » NFL Week 5 Picks Against the Spread
NFL Week 5 Picks Against the Spread

NFL Week 5 Picks Against the Spread

Publish Date: October 6, 2026

The NFL season is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are NFL week 5 picks against the spread. (Spreads are from Tallysight as of Tuesday morning)

Last week: 9-6-1

Season: 27-34-3

Thursday Night Football

Tampa Bay Buccaneers at Dallas Cowboys (-8.5)

Tampa Bay is starting undrafted rookie Jalon Daniels in place of Baker Mayfield. It will be hard for him to keep up with Dak Prescott on a short-week road game.

Pick: Cowboys

Sunday Morning

Philadelphia Eagles at Jacksonville Jaguars (-6.5) (Game in London, England)

The Eagles are struggling right now and playing the Jaguars isn’t a solution. Jacksonville’s defense has been great and the offense should do enough to cover in London.

Pick: Jaguars

Sunday Afternoon

Chicago Bears (-3) at Green Bay Packers

Chicago is playing well with backup quarterbacks, aided by running the ball well. In a tough division road game, that might be hard to do. Green Bay isn’t playing well, but they should battle well against backup quarterbacks, even if they are playing well.

Pick: Packers

Cincinnati Bengals (-7) at Miami Dolphins

T.J. Hockenson went down at the one-yard line for the Vikings and the Dolphins covered the spread for the first time of the season. Cincinnati has injury issues to their wide receivers, but they should still be able to do enough to cover against the Dolphins.

Pick: Bengals

Minnesota Vikings (-1.5) at New Orleans Saints

Brian Flores has his defense playing well and Kyler Murray is doing enough to get wins. The defense can confuse Tyler Shough, who has been inconsistent this season.

Pick: Vikings

Houston Texans (-6.5) at Tennessee Titans

Neither of these teams has won a game. The Texans have not played well defensively, despite the hype they received before the season. This is a game they should be able to get things going, as the Titans struggle to score. With C.J. Stroud playing well, they can cover on the road.

Pick: Texans

Las Vegas Raiders at New England Patriots (-3.5) 

The Patriots had their best offensive game last week against the Bills and that momentum could help them against the Raiders. Las Vegas is playing well, but it will be tough to keep it within a field goal in a game that is early and across the country.

Pick: Patriots

Indianapolis Colts at Pittsburgh Steelers (-2.5)

The Colts needed a while to get going in London and now travel back to the States. Pittsburgh has had extra time to prepare for this game, but the offense will not have enough playmakers to cover at home.

Pick: Colts

Cleveland Browns at New York Jets (-1.5)

Cleveland is on fire right now, but the Jets have a solid defense and have played some tough offenses the last few weeks. The Jets can slow down Cleveland and score enough to cover at home.

Pick: Jets

New York Giants at Washington Commanders (-3.5)

The Giants have only lost to the Rams this season. Defensively, they have played well and the offense has done enough to get wins. Washington could get Jayden Daniels back this week, but that isn’t a sure thing.

Pick: Giants

Sunday Evening

Denver Broncos (-3.5) at Los Angeles Chargers

Los Angeles is struggling to score points and they are turning over the ball too much. Denver’s offense isn’t playing the best either, but the defense can limit the Chargers and help them cover.

Pick: Broncos

San Francisco 49ers at Seattle Seahawks (-3)

The Seahawks have injury issues at running back, which could really hurt them against the 49ers. Brock Purdy is playing efficient football and the 49ers are running the ball well. They could at least keep it close on the road if not win outright.

Pick: 49ers

Detroit Lions (-4.5) at Arizona Cardinals

Detroit’s defense has been bad, but their offense should be good enough to cover against the Cardinals. Arizona is giving up 29.3 points per game and may not be able to keep up with the Lions.

Pick: Lions

Sunday Night Football

Baltimore Ravens at Atlanta Falcons (-1.5)

Lamar Jackson is questionable for this one, but even if he is out, Tyler Huntley has played well in his absence. The Ravens can limit the Falcons’ offense and can win on the road, even if Jackson is out.

Pick: Ravens

Monday Night Football

Buffalo Bills at Los Angeles Rams (-2.5)

The Bills’ defense has let them down and that isn’t a good recipe when they go on the road to play the Rams. Los Angeles should get a few key stops to win and cover at home.

Pick: Rams

Go to our NFL page for more articles and updates like NFL Week 5 Picks Against the Spread!

You can like The Game Haus on Facebook and follow us on Twitter for more sports and esports articles from great TGH writers!

 

Leave A Reply

* required
Read Also
NFL Week 8 Picks Against the Spread
The NFL season is here. Picking NFL games straight up is hard ...
NFL Week 6 Picks Against the Spread
The NFL season is here. Picking NFL games straight up is hard ...
NFL Week 4 Picks Against the Spread
The NFL season is here. Picking NFL games straight up is hard ...
NFL Week 3 Picks Against the Spread
The NFL season is here. Picking NFL games straight up is hard ...
NFL Week 2 Picks Against the Spread
The NFL season is here. Picking NFL games straight up is hard ...

The Game Haus covers gaming, esports and sports through focused ecosystems, guides, rankings, analysis and videos.





Explore:
Pokemon | Pokemon Champions | NFL | NFL Draft | Fantasy Football | College Football | Deadlock
Watch:
Pokemon Haus | Draft Haus | Dead Unlocked | The Game Haus
Follow:
TGH Sports on Twitter/X | TGH Esports on Twitter/X | Sports Facebook | Esports Facebook



Players must be 21 years of age or older or reach the minimum age for gambling in their respective state and located in jurisdictions where online gambling is legal. Please play responsibly. Bet with your head, not over it. If you or someone you know has a gambling problem, and wants help, call or visit: (a) the Council on Compulsive Gambling of New Jersey at 1-800-Gambler or www.800gambler.org; or (b) Gamblers Anonymous at 855-2-CALL-GA or www.gamblersanonymous.org.

×
Your Promo Code:
The bonus offer of was already opened in an additional window. If not, you can open it also by clicking the following link:
Play now