Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 5 Picks.
| Away | Home | Location | Cecil | Joe |
| Los Angeles Rams | Seattle | CenturyLink Field, Seattle | Seahawks | Rams |
| Arizona | Cincinnati | Paul Brown Stadium, Cincinnati | Cardinals | Cardinals |
| Buffalo | Tennessee | Nissan Stadium, Nashville | Bills | Titans |
| Chicago | Oakland | Tottenham Hotspur Stadium, London | Bears | Bears |
| Tampa Bay | New Orleans | Mercedes-Benz Superdome, New Orleans | Saints | Buccaneers |
| Minnesota | New York Giants | MetLife Stadium, East Rutherford | Vikings | Vikings |
| New York Jets | Philadelphia | Lincoln Financial Field, Philadelphia | Eagles | Eagles |
| Baltimore | Pittsburgh | Heinz Field, Pittsburgh | Ravens | Ravens |
| New England | Washington | FedEx Field, Landover | Patriots | Patriots |
| Jacksonville | Carolina | Bank of America Stadium, Charlotte | Panthers | Panthers |
| Atlanta | Houston | NRG Stadium, Houston | Texans | Texans |
| Denver | Los Angeles Chargers | Dignity Health Sports Park, Carson | Chargers | Chargers |
| Green Bay | Dallas | AT&T Stadium, Arlington | Packers | Cowboys |
| Indianapolis | Kansas City | Arrowhead Stadium, Kansas City | Chiefs | Chiefs |
| Cleveland | San Francisco | Levi’s Stadium, Santa Clara | 49ers | 49ers |
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