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NFL Week 3 Picks Against the Spread

Publish Date: September 21, 2021

NFL Week 3 is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are the NFL week 3 picks against the spread. (Spreads are from tallysight as of Tuesday afternoon)

Last week: 5-10-1, Season total: 11-20-1

Thursday Night Football

Carolina Panthers (-7.5) at Houston Texans 

Tyrod Taylor is officially out meaning Davis Mills will be the starting quarterback. The Panthers have allowed 10.5 points per game so far this season to help them go 2-0. They will feast on the rookie quarterback and Christian McCaffrey will help them control the ball.

Pick: Panthers

Sunday Afternoon

Washington Football Team at Buffalo Bills (-7.5)

Washington’s defense will keep them in most every game, even with Taylor Heinicke. Buffalo blew out Miami in week 2, but that was after an injury to Tua Tagovailoa. The Bills will win, but Washington will keep it close.

Pick: Washington

Cleveland Browns (-6.5) at Chicago Bears

The Bears narrowly escaped with a win over Cincinnati in week 2. Andy Dalton is hurt and may not play in this game, which could make it Justin Fields‘ first start. He looked shaky against the Bengals. The Browns will run the ball effectively and their defense will show up against whoever the Bears start at quarterback.

Pick: Browns

Baltimore Ravens (-7.5) at Detroit Lions

Detroit will be on a short week after playing Green Bay on Monday Night Football. They aren’t as bad as people thought they would be, but the Ravens should be able to run the ball and control the game against them. The Ravens’ defense will also cause some turnovers to help the cause.

Pick: Ravens

Arizona Cardinals (-7.5) at Jacksonville Jaguars

The Cardinals are 2-0 and look like they could have some big things in store this season. Their defense stepped up in week 1, while their offense has been on fire with Kyler Murray leading the way. Jacksonville has been turning the ball over too much and look like they are headed for another long season.

Pick: Cardinals

Los Angeles Chargers at Kansas City Chiefs (-6.5)

The Chiefs lost to the Ravens on the road, but that is one of their toughest games all season. They will want to regroup against the Chargers. Los Angeles has played good defense, but scoring has been difficult. They will not be able to catch up with the Chiefs.

Pick: Chiefs

New Orleans Saints at New England Patriots (-2.5)

In week 2, the Patriots benefitted from Zach Wilson throwing a lot of interceptions. The Saints will likely not throw that many interceptions, even if Jameis Winston is the quarterback. New Orleans should have some players back from COVID protocols as well to help them make it a close game.

Pick: Saints

Atlanta Falcons at New York Giants (-3.5) 

Both of these teams are likely going to have top 10 picks in the 2022 NFL Draft. The Giants have looked a little better than the Falcons so far, but may struggle to limit Calvin Ridley and Matt Ryan. Daniel Jones still doesn’t have great ball security and the Falcons may be able to take advantage to at least keep the game close.

Pick: Falcons

Cincinnati Bengals at Pittsburgh Steelers (-3.5)

The Bengals are giving up too many sacks on Joe Burrow. If T.J. Watt is able to go, the Bengals offense will likely continue to struggle to move the ball. Ben Roethlisberger is also banged up, but the Steelers should still be able to get the ball to their playmakers.

Pick: Steelers

Indianapolis Colts at Tennessee Titans (-5.5)

Carson Wentz may or may not play in this game with two sprained ankles. Even if he can play, there is no way he is effective with that injury. The Titans should be able to keep the ball on the ground and win the game, no matter who is at quarterback.

Pick: Titans

Sunday Evening

New York Jets at Denver Broncos (-10.5)

Zach Wilson is turning the ball over and the Broncos defense will feast in this home game. The Broncos should win easily.

Pick: Broncos

Miami Dolphins at Las Vegas Raiders (-3.5) 

Las Vegas has a distinct home-field advantage and have beaten two tough teams to begin the season. They can win and cover against the Dolphins, who may be without starting quarterback Tua Tagovailoa for this game.

Pick: Raiders

Tampa Bay Buccaneers (-1.5) at Los Angeles Rams

The Bucs are going to have to travel across the country for this one. It will be a tough road game, but Tom Brady is not infallible. They will lose some games this season and this is one they shouldn’t be favored in. Matthew Stafford cooled off in week 2, but he and Sean McVay will be ready for the Buccaneers.

Pick: Rams

Seattle Seahawks (-2.5) at Minnesota Vikings

Minnesota was a totally different team from week 1 to week 2, but both games ended up in a loss. Seattle has looked good in both weeks, but did allow Derrick Henry to run all over them in week 2, which resulted in a loss. The Seahawks should be able to go on the road and cover because of their offensive personnel being too much for Minnesota.

Pick: Seahawks

Sunday Night Football

Green Bay Packers at San Francisco 49ers (-3.5)

The 49ers seem to be the Packers’ kryptonite. This might be different though. San Francisco has not looked good with Jimmy Garoppolo under center. On top of that Brandon Aiyuk isn’t being used. They also have significant running back injuries. Aaron Rodgers should be able to lead his team to victory on the road.

Pick: Packers

Monday Night Football

Philadelphia Eagles at Dallas Cowboys (-4.5)

While the Eagles have looked better than expected, the Cowboys look like they have a much-improved defense. Their offense will need to continue to find their footing, but Dak Prescott looks good so far this season. The Cowboys should win and cover.

Pick: Cowboys

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