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NFL Week 15 Picks Against the Spread

NFL Week 15 Picks Against the Spread

Publish Date: December 9, 2025



The NFL season is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are NFL week 15 picks against the spread. (Spreads are from Tallysight as of Tuesday morning)

Last Week: 6-8

Season: 101-105-2

Thursday Night Football

Atlanta Falcons at Tampa Bay Buccaneers (-4)

Tampa Bay has been struggling lately, but need this win to get back on track. Atlanta has won just one of its last eight games, so this could help the Buccaneers get right and make the push towards the playoffs.

Pick: Buccaneers

Sunday Afternoon

Baltimore Ravens (-2.5) at Cincinnati Bengals

Baltimore is struggling. They’ve lost to the Bengals and the Steelers in the last two weeks. The Bengals are playing a lot better with Joe Burrow at quarterback after defeating the Ravens and losing a close one to the Bills. Cincinnati can probably win outright at home.

Pick: Bengals

Cleveland Browns at Chicago Bears (-7.5)

The Browns had some life on offense, but lost to the Titans last week. Chicago’s offense has been great this season and they should be able to cover at home.

Pick: Bears

Los Angeles Chargers at Kansas City Chiefs (-3.5)

Kansas City needs to win out if they want any hope of making the playoffs. Their defense could wreak havoc against the Chargers, as they have injuries along the offensive line.

Pick: Chiefs

Buffalo Bills at New England Patriots (-1.5)

The Patriots have played well this season, but it has been against an easier schedule. Buffalo’s defense can make a few key plays and Josh Allen can do the rest to help them win on the road.

Pick: Bills

Washington Commanders at New York Giants (-2.5)

Jayden Daniels was hurt against the Vikings, but could play this week. The Giants are coming off a bye, but have lost seven straight games. The Commanders with the points is the smart play and they may win the game on the road.

Pick: Commanders

Las Vegas Raiders at Philadelphia Eagles (-11.5)

Philadelphia needs a week to get the offense going and this could be it. The Raiders haven’t won any of their last seven games and have given up at least 24 points in each of the last four games. The Eagles should be able to keep the ball on the ground and score.

Pick: Eagles

New York Jets at Jacksonville Jaguars (-12.5)

The Jaguars have played well this sesason, even if it hasn’t always been the cleanest. Justin Fields could be put back in for the Jets and he only lost two games by this margin as a starter this season.

Pick: Jets

Arizona Cardinals at Houston Texans (-9.5)

Houston’s defense is nasty and Arizona has plenty of players who are injured. The Texans should be able to win and cover at home.

Pick: Texans

Sunday Evening

Green Bay Packers (-2.5) at Denver Broncos

Green Bay has won four straight games, which coincides with Toyotathon. Jordan Love seems to turn it on at that point of the year and the Packers’ receiving core is healthier. The Broncos’ defense plays well, but the offense has been limited at times.

Pick: Packers

Detroit Lions at Los Angeles Rams (-5.5)

The Rams have only lost once at home this season and are a pretty complete team. Detroit is still very talented, but have dropped every other game over the last nine weeks and that trend will likely continue this week. They should be able to keep it close in a loss.

Pick: Lions

 Carolina Panthers (-2.5) at New Orleans Saints

The Panthers are in the thick of the race for the NFC South. Playing at New Orleans won’t be easy and the Saints are coming off a win, but they should be able to win on the road.

Pick: Panthers

Tennessee Titans at San Francisco 49ers (-13.5)

Tennessee is coming off a win and their offense played well against a tough Browns’ defense. San Francisco will win off the bye, but the Titans can keep it between this large spread.

Pick: Titans

Indianapolis Colts at Seattle Seahawks (-13.5)

Right now, the Colts don’t know who is going to start for them at quarterback. Daniel Jones, Anthony Richardson and Daniel Jones are all hurt and Philip Rivers was brought in for a workout. Seattle’s defense should severely limit the Colts and help the team cover.

Pick: Seahawks

Sunday Night Football

Minnesota Vikings at Dallas Cowboys (-6)

The offensive output by the Vikings has been too inconsistent this season. Dallas has been better since the trade deadline on defense and the offense will do enough to cover.

Pick: Cowboys

Monday Night Football

Miami Dolphins at Pittsburgh Steelers (-3)

Miami has won their last four games and five of their last six. They have worked their way back into the playoff picture and can keep the streak going against the Steelers on Monday Night Football. Pittsburgh is below .500 in the last eight weeks.

Pick: Dolphins

 

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