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NFL Week 12 Picks Against the Spread

NFL Week 12 Picks Against the Spread

Publish Date: November 18, 2025

The NFL season is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are NFL week 12 picks against the spread. (Spreads are from Tallysight as of Tuesday morning)

Last Week: 7-8

Season: 80-84

Thursday Night Football

Buffalo Bills (-5.5) at Houston Texans

The Bills picked up a big win over a tough Buccaneers team last week. They feel like they are starting to find their stride. Houston will likely have CJ Stroud back from concussion protocol, which can help, but their offensive line could be bested.

Pick: Bills

Sunday Afternoon

Indianapolis Colts at Kansas City Chiefs (-3)

Kansas City needs to win most of their games down the stretch to make the playoffs. A road loss to the Broncos last week is nothing to be ashamed of and the game against the Colts should present an easier opportunity, as Indianapolis has two losses this season, both on the road.

Pick: Chiefs

Minnesota Vikings at Green Bay Packers (-6.5)

Minnesota has offensive issues as JJ McCarthy isn’t playing well and Justin Jefferson is visibly frustrated on the sidelines. Green Bay played a great game against the Giants with Jordan Love standing out. They should be able to protect their home turf and win by a touchdown.

Pick: Packers

New England Patriots (-8.5) at Cincinnati Bengals

The Patriots should win this game on the road, but this is a large spread, even against a team like the Bengals who have a terrible defense. Ja’Marr Chase will miss this game due to suspension, but the Bengals still have enough offensive firepower to keep this game close.

Pick: Bengals

New York Giants at Detroit Lions (-10)

Detroit is coming off a loss and will be focused. They usually cover in these situations and should be able to do so here against an interim coach and a banged-up team overall in the Giants.

Pick: Lions

New York Jets at Baltimore Ravens (-13)

New York is making Tyrod Taylor the starter in this game, but that likely won’t help the offensive output too much. Baltimore had a tough game against the Browns, but they have a good defense. They will likely have an easier time and cover this week.

Pick: Ravens

Pittsburgh Steelers at Chicago Bears (-3)

Aaron Rodgers is banged up and the Steelers’ offense is limited already. Chicago is on a hot streak and their offense should be able to outscore the Steelers.

Pick: Bears

Seattle Seahawks (-13) at Tennessee Titans

Seattle will win on the road against the Titans, but it could be closer than this large spread. The Titans played the Texans close last week, while the Seahawks turned the ball over a lot against the Rams. Seattle having to travel could also play a factor.

Pick: Titans

Sunday Evening

Cleveland Browns at Las Vegas Raiders (-2.5)

The Raiders and Browns are both having miserable seasons. Cleveland is expected to start Shedeur Sanders in place of the injured Dillon Gabriel. They may not be able to score a lot of points and the Raiders should be able to do enough to win and cover at home.

Pick: Raiders

Jacksonville Jaguars (-2.5) at Arizona Cardinals

Jacksonville is on the road in this one, but they are coming off a dominating win over the Chargers. Their defense is playing well and the Cardinals have injury issues at their skill positions, which should make things easier.

Pick: Jaguars

Atlanta Falcons at New Orleans Saints (-2.5)

While Kirk Cousins hasn’t looked great in relief of Michael Penix so far this season, a full week to prepare should help him. Atlanta’s defense can take advantage of Tyler Shough starting for the Saints.

Pick: Falcons

Philadelphia Eagles (-2.5) at Dallas Cowboys

The Eagles’ offense isn’t playing well, but they are winning games. Dallas has a defense that the Eagles can take advantage of, which should help them cover on the road.

Pick: Eagles

Sunday Night Football

Tampa Bay Buccaneers at Los Angeles Rams (-7)

Tampa Bay continues to play well despite their injuries. They should be able to keep this game close. The Rams will likely win, as they are playing well on both sides of the ball, but Baker Mayfield can keep it within a touchdown.

Pick: Buccaneers

Monday Night Football

Carolina Panthers at San Francisco 49ers (-6.5)

Bryce Young is coming off a great game, but has failed to find consistency during his NFL career. San Francisco should be able to protect their home turf and win by more than a touchdown, especially as they get healthier on the offensive side of the ball.

Pick: 49ers

 

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