Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 12 picks.
| Away | Home | Location | Cecil | Joe |
| Indianapolis | Houston | NRG Stadium, Houston | Colts | Texans |
| Tampa Bay | Atlanta | Mercedes-Benz Stadium, Atlanta | Falcons | Falcons |
| Denver | Buffalo | New Era Field, Buffalo | Bills | Bills |
| New York Giants | Chicago | Soldier Field, Chicago | Bears | Bears |
| Pittsburgh | Cincinnati | Paul Brown Stadium, Cincinnati | Steelers | Steelers |
| Miami | Cleveland | FirstEnergy Stadium, Cleveland | Browns | Browns |
| Carolina | New Orleans | Mercedes-Benz Superdome, New Orleans | Saints | Saints |
| Oakland | New York Jets | MetLife Stadium, East Rutherford | Raiders | Raiders |
| Seattle | Philadelphia | Lincoln Financial Field, Philadelphia | Seahawks | Seahawks |
| Detroit | Washington | FedEx Field, Landover | Lions | Lions |
| Jacksonville | Tennessee | Nissan Stadium, Nashville | Jaguars | Titans |
| Dallas | New England | Gillette Stadium, Foxboro | Cowboys | Patriots |
| Green Bay | San Francisco | Levi’s Stadium, Santa Clara | Packers | Packers |
| Baltimore | Los Angeles Rams | Los Angeles Memorial Coliseum, Los Angeles | Ravens | Ravens |
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