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NFL Week 10 Picks Against the Spread

NFL Week 10 Picks Against the Spread

Publish Date: November 10, 2026

The NFL season is here. Picking NFL games straight up is hard enough, but picking against the spread is even tougher. Here are NFL Week 9 picks against the spread. (Spreads are from Tallysight as of Tuesday morning)

Last week: 10-5

Season: 64-65-6

Thursday Night Football

Washington Commanders at New York Giants (-1.5)

The Giants are heating up and lead the NFC East. Arvell Reese had three sacks last week and can help the Giants’ pass rush make an impact in this game. The Giants are at home and can win and cover on a short week.

Pick: Giants

Sunday Morning

New England Patriots at Detroit Lions (-2.5) (Game in Munich, Germany)

While the Lions’ defense has some issues, the Patriots are really banged up on offense, specifically at the skill position players. Detroit should be able to get their offense back on track in this game to cover in Europe.

Pick: Lions

Sunday Afternoon

Buffalo Bills (-7.5) at New York Jets

The Bills will be happy to see the Jets’ defense after playing the Vikings in Week 9. Buffalo will be able to score and the Jets will likely struggle to keep up.

Pick: Bills

Carolina Panthers at New Orleans Saints (-1.5)

The Panthers have shown flashes of being a good team, but are inconsistent. New Orleans has struggled a bit more than that and nearly lost last week.

Pick: Panthers

Miami Dolphins at Indianapolis Colts (-2.5)

Indianapolis has started trading players away and may have completed more trades by the time the deadline comes. Miami is competing hard and Malik Willis can have a solid game against a bad Colts’ defense.

Pick: Dolphins

Minnesota Vikings at Green Bay Packers (-4.5)

Minnesota’s defense is awesome, but the offense is putrid. Green Bay is on fire and should be able to overcome the subpar offensive line play to score enough to cover.

Pick: Packers

Kansas City Chiefs (-3.5) at Atlanta Falcons

Atlanta is coming home from Europe and a bad performance against the Bengals. Kansas City has balance on offense and the defense is stepping up, so they should be able to win and cover on the road.

Pick: Chiefs

Houston Texans (-4.5) at Cleveland Browns 

Houston’s offense really opened up last week and the defense seems to be showing signs that they can be elite again. Cleveland’s offense will have a tough time moving the ball on Houston’s defense.

Pick: Texans

Jacksonville Jaguars (-10.5) at Tennessee Titans

Jacksonville was on a roll and made plenty of trades to upgrade their team. That should help them cover against the Titans, even if Cam Ward is showing signs of development.

Pick: Jaguars

Sunday Evening

Los Angeles Rams (-9) at Arizona Cardinals

The Rams’ defensive line stepped things up with Myles Garrett’s return. Arizona has quarterback issues with Gardner Minshew being hurt, so the Rams can cover, even with their wide receiver injuries.

Pick: Rams

Seattle Seahawks (-3.5) at Las Vegas Raiders

The Raiders have performed well against bad defenses and struggled against the good ones. Seattle has a good defense and should be able to run the ball well against the Raiders.

Pick: Seahawks

San Francisco 49ers (-3.5) at Dallas Cowboys

San Francisco is playing efficient football, despite some of their injuries. Dallas has been bad defensively and inconsistent on offense all season long.

Pick: 49ers

Sunday Night Football

Pittsburgh Steelers at Cincinnati Bengals (-3.5)

The Steelers won the first matchup between these teams and are coming off a bye. Cincinnati is rolling, but are coming back from Europe, which could make things a bit closer, even if they get a win.

Pick: Steelers

Monday Night Football

Los Angeles Chargers at Baltimore Ravens (-5.5)

The Ravens will have much better quarterback play with Jacoby Brissett under center. Baltimore should be able to score close to 30 points in the game, while the Chargers don’t have the firepower to keep up.

Pick: Ravens

 

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