Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 10 picks.
| Away | Home | Location | Cecil | Joe |
| Los Angeles Chargers | Oakland | RingCentral Coliseum, Oakland | Chargers | Chargers |
| Detroit | Chicago | Soldier Field, Chicago | Bears | Lions |
| Baltimore | Cincinnati | Paul Brown Stadium, Cincinnati | Ravens | Ravens |
| Buffalo | Cleveland | FirstEnergy Stadium, Cleveland | Bills | Bills |
| Kansas City | Tennessee | Nissan Stadium, Nashville | Chiefs | Chiefs |
| Atlanta | New Orleans | Mercedes-Benz Superdome, New Orleans | Saints | Saints |
| New York Giants | New York Jets | MetLife Stadium, East Rutherford | Jets | Giants |
| Arizona | Tampa Bay | Raymond James Stadium, Tampa | Bucs | Bucs |
| Miami | Indianapolis | Lucas Oil Stadium, Indianapolis | Colts | Colts |
| Carolina | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
| Los Angeles Rams | Pittsburgh | Heinz Field, Pittsburgh | Steelers | Rams |
| Minnesota | Dallas | AT&T Stadium, Arlington | Cowboys | Cowboys |
| Seattle | San Francisco | Levi’s Stadium, Santa Clara | Seahawks | Seahawks |
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