Cecil Walker and Joe DiTullio of the Third and The Don Football Show will make their picks every week of the NFL season. These are straight-up picks. Here are the NFL Week 1 Picks.
| Away | Home | Location | Cecil | Joe |
| Green Bay Packers | Chicago Bears | Soldier Field, Chicago | Bears | Packers |
| Tennessee Titans | Cleveland Browns | FirstEnergy Stadium, Cleveland | Browns | Browns |
| Baltimore Ravens | Miami Dolphins | Hard Rock Stadium, Miami Gardens | Ravens | Ravens |
| Atlanta Falcons | Minnesota Vikings | U.S. Bank Stadium, Minneapolis | Vikings | Vikings |
| Buffalo Bills | New York Jets | MetLife Stadium, East Rutherford | Jets | Jets |
| Washington Redskins | Philadelphia Eagles | Lincoln Financial Field, Philadelphia | Eagles | Eagles |
| Los Angeles Rams | Carolina Panthers | Bank of America Stadium, Charlotte | Panthers | Rams |
| Kansas City Chiefs | Jacksonville Jaguars | TIAA Bank Field, Jacksonville | Chiefs | Chiefs |
| Indianapolis Colts | Los Angeles Chargers | Dignity Health Sports Park, Carson | Chargers | Chargers |
| Cincinnati Bengals | Seattle Seahawks | CenturyLink Field, Seattle | Seahawks | Seahawks |
| New York Giants | Dallas Cowboys | AT&T Stadium, Arlington | Giants (upset pick) | Cowboys |
| Detroit Lions | Arizona Cardinals | State Farm Stadium, Glendale | Lions | Lions |
| San Francisco 49ers | Tampa Bay Buccaneers | Raymond James Stadium, Tampa | Buccaneers | Buccaneers |
| Pittsburgh Steelers | New England Patriots | Gillette Stadium, Foxboro | Patriots | Patriots |
| Houston Texans | New Orleans Saints | Mercedes-Benz Superdome, New Orleans | Saints | Saints |
| Denver Broncos | Oakland Raiders | Oakland Coliseum, Oakland | Broncos | Broncos |
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