The NFL season is already full of surprises, which makes it hard to pick winners. Cecil Walker and Joe DiTullio, of The Third and the Don Football Show, will do their best to try to predict the winners for every NFL game this season. Here are the NFL week 6 picks.
| Away | Home | Location | Joe | Cecil |
| Philadelphia | New York Giants | MetLife Stadium, East Rutherford | Eagles | Eagles |
| Tampa Bay | Atlanta | Mercedes-Benz Stadium, Atlanta | Falcons | Falcons |
| Pittsburgh | Cincinnati | Paul Brown Stadium, Cincinnati | Steelers | Bengals |
| Los Angeles Chargers | Cleveland | FirstEnergy Stadium, Cleveland | Chargers | Chargers |
| Seattle | Oakland | Wembley Stadium, London | Seahawks | Raiders |
| Chicago | Miami | Hard Rock Stadium, Miami Gardens | Bears | Bears |
| Arizona | Minnesota | U.S. Bank Stadium, Minneapolis | Vikings | Vikings |
| Indianapolis | New York Jets | MetLife Stadium, East Rutherford | Colts | Colts |
| Carolina | Washington | FedEx Field, Landover | Panthers | Panthers |
| Buffalo | Houston | NRG Stadium, Houston | Texans | Texans |
| Los Angeles Rams | Denver | Broncos Stadium at Mile High, Denver | Rams | Rams |
| Jacksonville | Dallas | AT&T Stadium, Arlington | Jaguars | Jags |
| Baltimore | Tennessee | Nissan Stadium, Nashville | Ravens | Ravens |
| Kansas City | New England | Gillette Stadium, Foxboro | Pats | Pats |
| San Francisco | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
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