The NFL season is already full of surprises, which makes it hard to pick winners. Cecil Walker and Joe DiTullio, of The Third and the Don Football Show, will do their best to try to predict the winners for every NFL game this season. Here are the NFL week 5 picks.
| Away | Home | Location | Joe | Cecil |
| Indianapolis | New England | Gillette Stadium, Foxboro | Patriots | Patriots |
| Tennessee | Buffalo | New Era Field, Buffalo | Titans | Titans |
| Miami | Cincinnati | Paul Brown Stadium, Cincinnati | Bengals | Bengals |
| Baltimore | Cleveland | FirstEnergy Stadium, Cleveland | Ravens | Ravens |
| Green Bay | Detroit | Ford Field, Detroit | Packers | Packers |
| Jacksonville | Kansas City | Arrowhead Stadium, Kansas City | Jags | Jags |
| Denver | New York Jets | MetLife Stadium, East Rutherford | Broncos | Broncos |
| Atlanta | Pittsburgh | Heinz Field, Pittsburgh | Steelers | Falcons |
| New York Giants | Carolina | Bank of America Stadium, Charlotte | Panthers | Panthers |
| Oakland | Los Angeles Chargers | StubHub Center, Carson | Chargers | Chargers |
| Minnesota | Philadelphia | Lincoln Financial Field, Philadelphia | Eagles | Vikings |
| Arizona | San Francisco | Levi’s Stadium, Santa Clara | 49ers | 49ers |
| Los Angeles Rams | Seattle | CenturyLink Field, Seattle | Rams | Rams |
| Dallas | Houston | NRG Stadium, Houston | Texans | Texans |
| Washington | New Orleans | Mercedes-Benz Superdome, New Orleans | Saints | Saints |
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