The NFL season is about to kick off. Cecil Walker and Joe DiTullio, of The Third and the Don Football Show, will make their picks for every NFL game this season. Here are the NFL week 1 picks.
| Away | Home | Location | Joe | Cecil |
| Atlanta | Philadelphia | Lincoln Financial Field, Philadelphia | Eagles | Eagles |
| Pittsburgh | Cleveland | FirstEnergy Stadium, Cleveland | Steelers | Steelers |
| Cincinnati | Indianapolis | Lucas Oil Stadium, Indianapolis | Colts | Bengals |
| Tennessee | Miami | Hard Rock Stadium, Miami Gardens | Titans | Titans |
| San Francisco | Minnesota | U.S. Bank Stadium, Minneapolis | Vikings | Vikings |
| Houston | New England | Gillette Stadium, Foxboro | Pats | Texans |
| Tampa Bay | New Orleans | Mercedes-Benz Superdome, New Orleans | Saints | Saints |
| Jacksonville | New York Giants | MetLife Stadium, East Rutherford | Jags | Jags |
| Buffalo | Baltimore | M&T Bank Stadium, Baltimore | Ravens | Ravens |
| Kansas City | Los Angeles Chargers | StubHub Center, Carson | Chargers | Chargers |
| Seattle | Denver | Broncos Stadium at Mile High, Denver | Broncos | Broncos |
| Washington | Arizona | U of Phoenix Stadium, Glendale | Cardinals | Redskins |
| Dallas | Carolina | Bank of America Stadium, Charlotte | Cowboys | Panthers |
| Chicago | Green Bay | Lambeau Field, Green Bay | Packers | Packers |
| New York Jets | Detroit | Ford Field, Detroit | Lions | Lions |
| Los Angeles Rams | Oakland | Oakland Coliseum, Oakland | Rams | Rams |
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