The 2022-23 NFL season has already been extremely entertaining. Bye weeks are starting to take place. This means that running backs like Joe Mixon and Rhamondre Stevenson will be out this week. On top of that injuries have started to mount up at this point of the season. It is always a great idea to evaluate backup options so that way fantasy managers are prepared if star players miss time. Here are the fantasy football week 10 running back rankings.
*Ratings are subject to change due to injury reports or possible move to reserve/COVID-19 list*
(Check out the section below for details on players already rumored to possibly miss this week and how their replacement options rank for the week)
| Category | Name | Opponent | Ranking |
| Must Start | Saquon Barkley | vs Houston Texans | RB1 |
| Must Start | Christian McCaffrey | vs Los Angeles Chargers | RB2 |
| Starting RB1 | Travis Etienne Jr. | vs Kansas City Chiefs | RB3 |
| Starting RB1 | Austin Ekeler | vs San Francisco 49ers | RB4 |
| Starting RB1 | Derrick Henry | vs Denver Broncos | RB5 |
| Starting RB1 | Alvin Kamara | vs Pittsburgh Steelers | RB6 |
| Starting RB1 | Nick Chubb | vs Miami Dolphins | RB7 |
| High-End RB2 | Josh Jacobs | vs Indianapolis Colts | RB8 |
| High-End RB2 | Dameon Pierce | vs New York Giants | RB9 |
| High-End RB2 | Jonathan Taylor* | vs Las Vegas Raiders | RB10 |
| High-End RB2 | Dalvin Cook | vs Buffalo Bills | RB11 |
| High-End RB2 | Kenneth Walker III | vs Tampa Bay Buccaneers | RB12 |
| High-End RB2 | Cordarrelle Patterson | vs Carolina Panthers | RB13 |
| High-End RB2 | Leonard Fournette | vs Seattle Seahawks | RB14 |
| Starting RB2 | D’Andre Swift | vs Chicago Bears | RB15 |
| Starting RB2 | David Montgomery | vs Detriot Lions | RB16 |
| Low RB2 | Najee Harris | vs New Orleans Saints | RB17 |
| Low RB2 | Jamaal Williams | vs Chicago Bears | RB18 |
| Low RB2 | Aaron Jones* | vs Dallas Cowboys | RB19 |
| Low RB2 | D’Onta Foreman | vs Atlanta Falcons | RB20 |
| Low RB2 | Raheem Mostert | vs Cleveland Browns | RB21 |
| Low RB2 | Ezekiel Elliott* | vs Green Bay Packers | RB22 |
| Flex | Khalil Herbert | vs Detroit Lions | RB23 |
| Flex | Jeff Wilson Jr. | vs Cleveland Browns | RB24 |
| Flex | Tony Pollard | vs Green Bay Packers | RB25 |
| Flex | Clyde Edwards-Helaire | vs Jacksonville Jaguars | RB26 |
| Flex | James Conner | vs Los Angeles Rams | RB27 |
| Flex | Chuba Hubbard | vs Atlanta Falcons | RB28 |
| Flex | Devin Singletary | vs Minnesota Vikings | RB29 |
| Flex | Antonio Gibson | vs Philadelphia Eagles | RB30 |
| Flex | Tyler Allgeier | vs Carolina Panthers | RB31 |
| Flex | Kareem Hunt | vs Miami Dolphins | RB32 |
| Deep League Flex | Darrell Henderson | vs Arizona Cardinals | RB33 |
| Deep League Flex | Jerick McKinnon | vs Jacksonville Jaguars | RB34 |
| Deep League Flex | Rachaad White | vs Seattle Seahawks | RB35 |
| Deep League Flex | Brian Robinson Jr. | vs Philadelphia Eagles | RB36 |
| Deep League Flex | Isaiah Pacheco | vs Jacksonville Jaguars | RB37 |
| Deep League Flex | Melvin Gordon | vs Tennessee Titans | RB38 |
| Deep League Flex | AJ Dillon | vs Dallas Cowboys | RB39 |
| Deep League Flex | J.D. McKissic* | vs Philadelphia Eagles | RB40 |
| Leave on the Bench | Eno Benjamin | vs Los Angeles Rams | RB41 |
| Leave on the Bench | Cam Akers | vs Arizona Cardinals | RB42 |
| Leave on the Bench | Latavius Murray | vs Tennessee Titans | RB43 |
| Leave on the Bench | Dontrell Hilliard | vs Denver Broncos | RB44 |
| Leave on the Bench | Nyheim Hines | vs Minnesota Vikings | RB45 |
| Leave on the Bench | Kenneth Gainwell | vs Washington Commanders | RB46 |
| Leave on the Bench | Deon Jackson | vs Las Vegas Riaders | RB47 |
| Leave on the Bench | Chase Edmonds | vs Tennessee Titans | RB48 |
| Leave on the Bench | Rex Burkhead | vs New York Giants | RB49 |
| Leave on the Bench | Jaylen Warren | vs New Orleans Saints | RB50 |
| Leave on the Bench | Caleb Huntley | vs Carolina Panthers | RB51 |
| Leave on the Bench | Alexander Mattison | vs Buffalo Bills | RB52 |
| Leave on the Bench | Mark Ingram* | vs Pittsburgh Steelers | RB53 |
| Leave on the Bench | JaMycal Hasty | vs Kansas City Chiefs | RB54 |
| Leave on the Bench | Elijah Mitchell* | vs Los Angeles Chargers | RB55 |
| Leave on the Bench | James Cook | vs Minnesota Vikings | RB56 |
| Leave on the Bench | Kyle Juszczyk* | vs Los Angeles Chargers | RB57 |
| Leave on the Bench | Ameer Abdullah | vs Indianapolis Colts | RB58 |
RB10 Jonathan Taylor, Indianapolis Colts
Jonathan Taylor missed last week’s game against the New England Patriots with an ankle injury. If he was to miss this week’s game against the Las Vegas Raiders Deon Jackson would move up to RB25 between Tony Pollard and Clyde Edwards-Helaire.
RB19 Aaron Jones, Green Bay Packers
Aaron Jones suffered an ankle injury last week against the Detroit Lions. The early reports are that he should be able to play this week. But if he doesn’t play this week against the Dallas Cowboys AJ Dillon moves up RB25 between Tony Pollard and Clyde Edwards-Helaire.
RB22 Ezekiel Elliott, Dallas Cowboys
Ezekiel Elliott missed Dallas’ last game against the Chicago Bears with a knee injury. He missed practice on Monday due to the injury. If Elliott misses this week’s game against the Green Bay Packers Tony Pollard moves up to RB9 between Josh Jacobs and Dameon Pierce.
RB40 J.D. McKissic, Washington Commanders
J.D. McKissic last week’s game against the Minnesota Vikings with a neck injury. If McKissic was to miss this week’s game against the Minnesota Vikings Antonio Gibson and Brian Robinson retain their rankings.
RB53 Mark Ingram, New Orleans Saints
Mark Ingram missed last week’s game against the Baltimore Ravens with a knee injury. If Ingram misses next week’s game against the Pittsburgh Steelers Dwayne Washington will backup Alvin Kamara.
San Francisco 49ers Running Backs: RB55 Elijah Mitchell & RB57 Kyle Juszczyk
Elijah Mitchell is expected to be activated off of injured reserve after suffering a knee injury in Week 1. Kyle Juszczyk missed San Francisco’s game against the Los Angeles Rams with a finger injury.
If Mitchell is inactive for Sunday’s game against the Los Angeles Chargers Tyrion Davis-Price would slot in at RB55 where Mitchell currently is slotted.
If Juszczyk doesn’t play for the 49ers expect to see more two tight end sets for this offense throughout the game.
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