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Fantasy Football Defenses to Stream Week 4

Fantasy Football Defenses to Stream Week 4

Publish Date: September 22, 2025

One of the biggest strategies in fantasy football is streaming defenses. Each week owners will look at matchups and make waiver wire acquisitions to find their starting defense. Here are fantasy football defenses to stream week 4.

(Note: All defenses mentioned are owned in less than 50 percent of ESPN leagues. Stats from before Monday Night Football)

1. New England Patriots

The Patriots fantasy defense ranks 10th in the league at 7.0 points per game. They have one double-digit scoring performance, which was against the Dolphins, and no negative scoring games. They have three interceptions and nine sacks on the season. 

In week 4, the Patriots play the Carolina Panthers. The Panthers are averaging 20.7 points per game, but that is bolstered by their blowout of the Falcons in week 3. The Patriots can limit Bryce Young, especially if Christian Gonzalez can come back after being questionable, but ultimately missing week 3. New England is rostered in 49 percent of ESPN leagues. 

2. San Francisco 49ers

San Francisco is tied for 10th in the league at 7.0 points per game as a defense. They have one double-digit scoring game, which was a 10-point outing against the Seahawks. The 49ers have no negative scoring games. So far on the season, San Francisco has registered three fumble recoveries and five sacks. 

Their matchup in week 4 is with the Jacksonville Jaguars. The Jaguars average 23.3 points per game, but have some struggles on offense, as star wide receiver Brian Thomas Jr. has failed to produce up to his potential. With Robert Saleh running the defense again, it could be tough for the Jaguars to move the ball if Thomas Jr. doesn’t get things going. The 49ers are rostered in 33.5 percent of ESPN leagues. 

3. Los Angeles Chargers

The Chargers rank 15th as a fantasy defense at 6.7 points per game. They have one double-digit scoring output, which was against the Raiders. Los Angeles doesn’t have a negative scoring game yet this season. In their three division games so far, they have three interceptions and seven sacks. 

This week, the Chargers will play the New York Giants. The Giants scored a lot of points against the Cowboys in week 2, but they have scored just 15 points in their other two games. Brian Daboll has to get in the win column soon to save his job, so a change to rookie quarterback Jaxson Dart could be in store, which will likely take some time for him to be comfortable. If Russell Wilson continues starting, the Chargers can limit the big plays and do well. They are rostered in 12.4 percent of ESPN leagues. 

4. Arizona Cardinals

Arizona scores seven fantasy points per game, ranking them 10th in the league. They scored 12 points against the Panthers, which is their only double-digit outing of the year. The Cardinals have no negative scoring games. Arizona has one touchdown, two interceptions, one fumble recovery, five sacks and one safety on the season. 

In week 4, the Cardinals play the Seattle Seahawks. The Seahawks have scored a lot of points in the last two weeks, but there still is some concern with their offense with Sam Darnold at quarterback. Arizona should be able to limit the Seahawks, as Seattle scored just 13 points in their one divisional game so far this season. The Cardinals are rostered in 27.9 percent of ESPN leagues. 

5. Chicago Bears

The Bears have been below-average as a fantasy defense this season, ranking 23rd at 4.0 points per game. They have two double-digit scoring games, which were against the Vikings and Cowboys. Chicago scored -11 points against the Detroit Lions in week 2. The Bears have one touchdown, four interceptions, one fumble recovery and five sacks this season. 

This week, the Bears play the Las Vegas Raiders. The Bears have had some boom or bust performances, but they should be able to play well against the Raiders, who have scored just 17.7 points per game, with that being bolstered by some garbage-time scoring against the Commanders in week 3. The Raiders can take some deep shots downfield, but are struggling to run the ball up to their potential. Chicago can shut down the run and make it tougher on the Raiders. They are rostered in just 4.6 percent of ESPN leagues. 

 

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