Cecil Walker (The Third) and Joe DiTullio (The Don) give their week one NFL Picks. These picks are straight up and don’t take into account any spreads.
| Away Team | Home Team | Joe | Cecil |
| Carolina Panthers | Denver Broncos (2 Points) | Panthers | Panthers |
| Tampa Bay Bucaneers | Atlanta Falcons | Bucs | Falcons |
| Minnesota Vikings | Tennessee Titans | Vikings | Vikings |
| Cleveland Browns | Philadelphia Eagles | Browns | Browns |
| Cincinnati Bengals | New York Jets | Bengals | Bengals |
| Oakland Raiders | New Orleans Saints | Saints | Raiders |
| San Diego Chargers | Kansas City Chiefs | Chiefs | Chiefs |
| Buffalo Bills | Baltimore Ravens | Ravens | Bills |
| Chicago Bears | Houston Texans | Texans | Texans |
| Green Bay Packers | Jacksonville Jaguars | Packers | Packers |
| Miami Dolphins | Seattle Seahawks | Seahawks | Seahawks |
| New York Giants | Dallas Cowboys | Giants | Giants |
| Detroit Lions | Indianapolis Colts | Colts | Colts |
| New England Patriots | Arizona Cardinals (2 Points) | Cardinals | Cardinals |
| Pittsburgh Steelers | Washington Redskins (2 Points) | Steelers | Steelers |
| Los Angeles Rams | San Francisco 49ers (2 Points) | Rams | Rams |