Rob Doerger and Joe DiTullio (Staff writers and personalities on the DiTullio and Doerger College Sports Show), pick every game in the week one slate for FBS.
| Away | Home | Location | Rob | Joe |
| Presbyterian College | Central Michigan | Kelly/Shorts Stadium, Mount Pleasant, MI | C. Mich | CMU |
| Charlotte | #19 Louisville | Papa John’s Cardinal Stadium, Louisville, KY | Louisville | Louisville |
| Tulane | Wake Forest | BB&T Field, Winston-salem, NC | Wake | Wake |
| Tennessee-Martin | Cincinnati | Nippert Stadium, Cincinnati, OH | Cincy | Cincy |
| Maine | Connecticut | Rentschler Field, East Hartford, CT | Uconn | Uconn |
| William & Mary | NC State | Carter-Finley Stadium, Raleigh, NC | NC State | NC State |
| Indiana | Florida Intl | FIU Stadium, Miami, FL | Indiana | IU |
| Appalachian State | #9 Tennessee | Neyland Stadium, Knoxville, TN | Tennessee | Tennessee |
| South Carolina | Vanderbilt | Vanderbilt Stadium, Nashville, TN | Vandy | Vanderbilt |
| Southern Utah | Utah | Rice-Eccles Stadium, Salt Lake City, UT | Utah | Utah |
| Weber State | Utah State | Romney Stadium, Logan, UT | Utah St | Utah State |
| Rice | Western Kentucky | L.T. Smith Stadium, Bowling Green, KY | WKU | Wku |
| Oregon State | Minnesota | TCF Bank Stadium, Minneapolis, MN | Minnesota | Minnesota |
| South Dakota | New Mexico | University Stadium , Albuquerque, NM | New Mexico | UNM |
| Montana State | Idaho | Kibbie Dome, Moscow, ID | Idaho | Idaho |
| Jackson State | UNLV | Sam Boyd Stadium, Las Vegas, NV | UNLV | UNLV |
| Mississippi Valley State | Eastern Michigan | Rynearson Stadium, Ypsilanti, MI | E. Mich | EMU |
| Ball State | Georgia State | Georgia Dome, Atlanta, GA | Georgia St | Ga State |
| Albany | Buffalo | UB Stadium, Buffalo, NY | Buffalo | Buffalo |
| Colgate | Syracuse | Carrier Dome, Syracuse, NY | Syracuse | Syracuse |
| Army | Temple | Lincoln Financial Field, Philadelphia, PA | Temple | Temple |
| Furman | #12 Michigan State | Spartan Stadium , East Lansing, MI | Sparty | MSU |
| Northwestern State | #23 Baylor | McLane Stadium, Waco, TX | Baylor | Baylor |
| Colorado State | Colorado | Sports Authority Field, Denver, CO | Colorado | Colorado |
| Kansas State | #8 Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| Toledo | Arkansas State | Centennial Bank Stadium, Jonesboro, AR | Toledo | Toledo |
| Cal Poly | Nevada | Mackay Stadium, Reno, NV | Nevada | Nevada |
| Georgia Tech | Boston College | Aviva Stadium, Dublin | GT | GT |
| #3 Oklahoma | #15 Houston | NRG Stadium, Houston, TX | Oklahoma | Oklahoma |
| Fordham | Navy | Navy-Marine Corps Memorial Stadium, Annapolis, MD | Navy | Navy |
| Eastern Kentucky | Purdue | Ross-Ade Stadium, West Lafayette, IN | Purdue | Purdue |
| Bowling Green | #6 Ohio State | Ohio Stadium, Columbus, OH | Ohio St | OSU |
| Western Michigan | Northwestern | Ryan Field, Evanston, IL | NW | NW |
| Hawaii | #7 Michigan | Michigan Stadium, Ann Arbor, MI | Michigan | Mich |
| Margin of Victory | 44 | 39 | ||
| Boise State | Louisiana Lafayette | Cajun Field, Lafayette, LA | Boise | Boise |
| South Alabama | Mississippi State | Davis Wade Stadium, Starkville, MS | Miss St | Miss St |
| Missouri | West Virginia | Milan Puskar Stadium, Morgantown, WV | WVU | WVU |
| Howard | Maryland | Maryland Stadium, College Park, MD | Maryland | Maryland |
| Liberty | Virginia Tech | Lane Stadium, Blacksburg, VA | VT | Va Tech |
| Villanova | Pittsburgh | Heinz Field, Pittsburgh, PA | Pitt | Pitt |
| Abilene Christian | Air Force | Falcon Stadium, Usaf Academy, CO | Air Force | AF |
| Rutgers | #14 Washington | Husky Stadium, Seattle, WA | Washington | Wash |
| #16 UCLA | Texas A&M | Kyle Field, College Station, TX | UCLA | TAMU |
| #5 LSU | Wisconsin | Lambeau Field, Green Bay, WI | LSU | LSU |
| Richmond | Virginia | Scott Stadium, Charlottesville, VA | Virginia | Virginia |
| Kent State | Penn State | Beaver Stadium, University Park, PA | Ped St | Penn State |
| Miami (OH) | #17 Iowa | Kinnick Stadium, Iowa City, IA | Iowa | Iowa |
| Texas State | Ohio | Peden Stadium, Athens, OH | Ohio | Ohio |
| Murray State | Illinois | Memorial Stadium , Champaign, IL | Illini | Illinois |
| Southeastern Louisiana | #21 Oklahoma State | Boone Pickens Stadium, Stillwater, OK | OK St | OK St |
| Louisiana Tech | Arkansas | Razorback Stadium, Fayetteville, AR | Arkansas | Ark |
| UC Davis | #24 Oregon | Autzen Stadium, Eugene, OR | Ducks | Oregon |
| #18 Georgia | #22 North Carolina | Georgia Dome, Atlanta, GA | Georgia | Georgia |
| Southern Illinois | Florida Atlantic | FAU Football Stadium, Boca Raton, FL | Salukis | FAU |
| Hampton | Old Dominion | S.B. Ballard Stadium, Norfolk, VA | Old Dom | ODU |
| North Carolina Central | Duke | Wallace Wade Stadium, Durham, NC | Duke | Duke |
| Western Carolina | East Carolina | Dowdy-Ficklen Stadium, Greenville, NC | ECU | ECU |
| Florida A&M | Miami | Hard Rock Stadium, Miami, FL | Miami | Miami |
| Savannah State | Georgia Southern | Allen E. Paulson Stadium, Statesboro, GA | Geo South | Geo South |
| Austin Peay | Troy | Veterans Memorial Stadium , Troy, AL | Troy | Troy |
| VMI | Akron | InfoCision Stadium, Akron, OH | Akron | Akron |
| Alabama A&M | Middle Tennessee | Floyd Stadium, Murfreesboro, TN | MTSU | MTSU |
| SMU | North Texas | Mean Green Stadium, Denton, TX | SMU | SMU |
| San José State | Tulsa | Chapman Stadium, Tulsa, OK | Tulsa | Tulsa |
| Towson | South Florida | Raymond James Stadium, Tampa, FL | USF | USF |
| South Carolina State | UCF | Bright House Networks Stadium, Orlando, FL | UCF | UCF |
| Rhode Island | Kansas | Memorial Stadium , Lawrence, KS | Kansas | Kansas |
| Southeast Missouri State | Memphis | Liberty Bowl Memorial Stadium, Memphis, TN | Memphis | Memphis |
| Alabama State | Texas San Antonio | Alamodome, San Antonio, TX | UTSA | UTSA |
| Southern | Louisiana Monroe | Malone Stadium, Monroe, LA | ULM | ULM |
| Southern Mississippi | Kentucky | Commonwealth Stadium, Lexington, KY | Kentucky | UK |
| Massachusetts | #25 Florida | Ben Hill Griffin Stadium, Gainesville, FL | Gators | Florida |
| #20 USC | #1 Alabama | AT&T Stadium, Arlington, TX | Tide | Bama |
| Northern Iowa | Iowa State | Jack Trice Stadium, Ames, IA | Iowa St | Iowa State |
| Fresno State | Nebraska | Memorial Stadium , Lincoln, NE | Nebraska | Nebraska |
| Eastern Washington | Washington State | Martin Stadium, Pullman, WA | Wash St | Wash St |
| New Mexico State | UTEP | Sun Bowl, El Paso, TX | UTEP | Utep |
| South Dakota State | #13 TCU | Amon G. Carter Stadium, Fort Worth, TX | TCU | TCU |
| Stephen F Austin | Texas Tech | Jones AT&T Stadium, Lubbock, TX | TT | Ttu |
| New Hampshire | San Diego State | Qualcomm Stadium, San Diego, CA | SDSU | SDSU |
| #2 Clemson | Auburn | Jordan-Hare Stadium, Auburn, AL | Clemson | Clemson |
| BYU | Arizona | University of Phoenix Stadium, Glendale, AZ | Arizona | BYU |
| Northern Illinois | Wyoming | War Memorial Stadium , Laramie, WY | NIU | NIU |
| Northern Arizona | Arizona State | Sun Devil Stadium, Tempe, AZ | Arizona St | ASU |
| #10 Notre Dame | Texas | Royal Texas Memorial Stadium, Austin, TX | Irish | ND |
| #11 Ole Miss | #4 Florida State | Florida Citrus Bowl, Orlando, FL | FSU | Ole Miss |
| Gameday Guest Picker (Green Bay, WI) | Aaron Rodgers | Jared Abbrederis |