Rob Doerger and Joe DiTullio (personalities on the DiTullio and Doerger College Sports Show) make their picks for all week six FBS college football games.
| Away | Home | Location | Rob | Joe |
| Georgia Southern | Arkansas State | Centennial Bank Stadium, Jonesboro, AR | GSU | GSU |
| Temple | Memphis | Liberty Bowl Memorial Stadium, Memphis, TN | Memphis | Memphis |
| Western Kentucky | Louisiana Tech | Joe Aillet Stadium, Ruston, LA | WKU | WKU |
| #3 Clemson | Boston College | Alumni Stadium , Chestnut Hill, MA | Clemson | Clemson |
| Tulane | UCF | Bright House Networks Stadium, Orlando, FL | UCF | UCF |
| SMU | Tulsa | Chapman Stadium, Tulsa, OK | Tulsa | SMU |
| #19 Boise State | New Mexico | University Stadium , Albuquerque, NM | Boise | Boise |
| Cincinnati | Connecticut | Rentschler Field, East Hartford, CT | Cincy | Cincy |
| East Carolina | South Florida | Raymond James Stadium, Tampa, FL | USF | USF |
| Southern Mississippi | Texas San Antonio | Alamodome, San Antonio, TX | S. Miss | So Miss |
| TCU | Kansas | Memorial Stadium , Lawrence, KS | TCU | TCU |
| Iowa | Minnesota | TCF Bank Stadium, Minneapolis, MN | Minnesota | Iowa |
| Maryland | Penn State | Beaver Stadium, University Park, PA | Penn St | PSU |
| Texas | #20 Oklahoma | Cotton Bowl, Dallas, TX | Oklahoma | Oklahoma |
| Notre Dame | NC State | Carter-Finley Stadium, Raleigh, NC | ND | ND |
| LSU | #18 Florida | Ben Hill Griffin Stadium, Gainesville, FL | LSU | LSU |
| Auburn | Mississippi State | Davis Wade Stadium, Starkville, MS | Miss St | Auburn |
| Georgia Tech | Pittsburgh | Heinz Field, Pittsburgh, PA | Pitt | Ga Tech |
| Bowling Green | Ohio | Peden Stadium, Athens, OH | Ohio | Ohio |
| Miami (OH) | Akron | InfoCision Stadium, Akron, OH | Akron | Akron |
| Toledo | Eastern Michigan | Rynearson Stadium, Ypsilanti, MI | Toledo | Toledo |
| #6 Houston | Navy | Navy-Marine Corps Memorial Stadium, Annapolis, MD | Houston | Houston |
| Iowa State | Oklahoma State | Boone Pickens Stadium, Stillwater, OK | OK State | Ok State |
| Ball State | Central Michigan | Kelly/Shorts Stadium, Mount Pleasant, MI | C. Mich | CMU |
| Indiana | #2 Ohio State | Ohio Stadium, Columbus, OH | OSU | OSU |
| Purdue | Illinois | Memorial Stadium , Champaign, IL | Illini | Illinois |
| Texas State | Georgia State | Georgia Dome, Atlanta, GA | GSU | GSU |
| Charlotte | Florida Atlantic | FAU Football Stadium, Boca Raton, FL | FAU | FAU |
| #25 Virginia Tech | #17 North Carolina | Kenan Stadium, Chapel Hill, NC | UNC | UNC |
| Kent State | Buffalo | UB Stadium, Buffalo, NY | Buffalo | Buffalo |
| Air Force | Wyoming | War Memorial Stadium , Laramie, WY | AF | AF |
| Army | Duke | Wallace Wade Stadium, Durham, NC | Army | Duke |
| BYU | Michigan State | Spartan Stadium , East Lansing, MI | BYU | BYU |
| #9 Tennessee | #8 Texas A&M | Kyle Field, College Station, TX | Texas A&M | TAMU |
| #21 Colorado | USC | Los Angeles Memorial Coliseum, Los Angeles, CA | USC | USC |
| Vanderbilt | Kentucky | Commonwealth Stadium, Lexington, KY | Kentucky | UK |
| Hawai’i | San José State | CEFCU Stadium – Home of the Spartans, San Jose, CA | SJSU | SJSU |
| Massachusetts | Old Dominion | S.B. Ballard Stadium, Norfolk, VA | Umass | ODU |
| Northern Illinois | Western Michigan | Waldo Stadium, Kalamazoo, MI | WMU | WMU |
| Fresno State | Nevada | Mackay Stadium, Reno, NV | Nevada | Nevada |
| Syracuse | Wake Forest | BB&T Field, Winston-salem, NC | Wake | Wake |
| Marshall | North Texas | Apogee Stadium, Denton, TX | Marshall | Marshall |
| #1 Alabama | #16 Arkansas | Razorback Stadium, Fayetteville, AR | Bama | Bama |
| Idaho | Louisiana Monroe | Malone Stadium, Monroe, LA | ULM | ULM |
| #4 Michigan | Rutgers | High Point Solutions Stadium, Piscataway, NJ | Michigan | Michigan |
| Margin of Victory | 44 | 32 | ||
| Texas Tech | Kansas State | Bill Snyder Family Stadium, Manhattan, KS | Kansas St | TTU |
| Georgia | South Carolina | Williams-Brice Stadium, Columbia, SC | Georgia | Georgia |
| #5 Washington | Oregon | Autzen Stadium, Eugene, OR | Washington | Washington |
| Florida Intl | UTEP | Sun Bowl, El Paso, TX | UTEP | UTEP |
| #23 Florida State | #10 Miami | Hard Rock Stadium, Miami, FL | Miami | Miami |
| California | Oregon State | Reser Stadium, Corvallis, OR | Cal | Cal |
| Arizona | #24 Utah | Rice-Eccles Stadium, Salt Lake City, UT | Utah | Utah |
| Utah State | Colorado State | Hughes Stadium , Fort Collins, CO | Col St | Col State |
| UCLA | Arizona State | Sun Devil Stadium, Tempe, AZ | UCLA | UCLA |
| Washington State | #15 Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| UNLV | San Diego State | Qualcomm Stadium, San Diego | SDSU | SDSU |
| Gameday Guest Picker (College Station, TX) | Dude Perfect | Dude Perfect |