College football has seen some crazy things already, but there are a lot of ranked matchups this weekend that can bring more clarity on who the contenders are. As with every week Joe DiTullio and Rob Doerger will make their picks for every single FBS college football game. Here are the week five picks:
| Away | Home | Location | Rob | Joe |
| Texas | Iowa State | Jack Trice Stadium, Ames, IA | Texas | Texas |
| #14 Miami | Duke | Wallace Wade Stadium, Durham, NC | Miami | Miami |
| Nebraska | Illinois | Memorial Stadium , Champaign, IL | Nebraska | Nebaska |
| BYU | Utah State | Romney Stadium, Logan, UT | Utah St | BYU |
| #5 USC | #16 Washington St | Martin Stadium, Pullman, WA | USC | Wazzu |
| Northwestern | #10 Wisconsin | Camp Randall Stadium, Madison, WI | Wisconsin | Wisconsin |
| #18 South Florida | East Carolina | Dowdy-Ficklen Stadium, Greenville, NC | USF | USF |
| Margin of Victory | 28 | 34 | ||
| Vanderbilt | #21 Florida | Ben Hill Griffin Stadium, Gainesville, FL | Florida | Florida |
| Houston | Temple | Lincoln Financial Field, Philadelphia, PA | Houston | Houston |
| New Mexico State | Arkansas | Razorback Stadium, Fayetteville, AR | Arkansas | Arkansas |
| Maryland | Minnesota | TCF Bank Stadium, Minneapolis, MN | Minnesota | Minnesota |
| Rice | Pittsburgh | Heinz Field, Pittsburgh, PA | Pitt | Pitt |
| North Carolina | Georgia Tech | Bobby Dodd Stadium, Atlanta, GA | GT | Ga Tech |
| Syracuse | NC State | Carter-Finley Stadium, Raleigh, NC | NC State | NC State |
| Central Michigan | Boston College | Alumni Stadium , Chestnut Hill, MA | BC | BC |
| Indiana | #4 Penn State | Beaver Stadium, University Park, PA | Penn St | PSU |
| #7 Georgia | Tennessee | Neyland Stadium, Knoxville, TN | Georgia | UGA |
| Murray State | #17 Louisville | Papa John’s Cardinal Stadium, Louisville, KY | Louisville | Louisville |
| Florida State | Wake Forest | BB&T Field, Winston-salem, NC | FSU | FSU |
| Ohio | UMass | Warren McGuirk Alumni Stadium, Amherst, MA | Ohio | Ohio |
| Baylor | Kansas State | Bill Snyder Family Stadium, Manhattan, KS | Kansas St | KSU |
| UTEP | Army | Michie Stadium, West Point, NY | Army | Army |
| Navy | Tulsa | Chapman Stadium, Tulsa, OK | Navy | Navy |
| Buffalo | Kent State | Dix Stadium, Kent, OH | Buffalo | Buffalo |
| Texas State | Wyoming | War Memorial Stadium , Laramie, WY | Wyoming | Wyoming |
| Connecticut | SMU | Gerald J. Ford Stadium, Dallas, TX | SMU | SMU |
| Arizona State | Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| Eastern Michigan | Kentucky | Commonwealth Stadium, Lexington, KY | Kentucky | UK |
| Iowa | Michigan State | Spartan Stadium , East Lansing, MI | Michigan St | Iowa |
| Miami (OH) | #22 Notre Dame | Notre Dame Stadium, Notre Dame, IN | ND | ND |
| #24 Mississippi State | #13 Auburn | Jordan-Hare Stadium, Auburn, AL | Auburn | Mississippi State |
| Akron | Bowling Green | Doyt Perry Stadium, Bowling Green, OH | Akron | BG |
| Troy | #25 LSU | Tiger Stadium , Baton Rouge, LA | LSU | LSU |
| Charlotte | Florida Intl | FIU Stadium, Miami, FL | FIU | FIU |
| Middle Tennessee | Florida Atlantic | FAU Football Stadium, Boca Raton, FL | MTSU | MTSU |
| South Alabama | Louisiana Tech | Joe Aillet Stadium, Ruston, LA | La Tech | La Tech |
| Marshall | Cincinnati | Nippert Stadium, Cincinnati, OH | Marshall | UC |
| North Texas | Southern Mississippi | M. M. Roberts Stadium, Hattiesburg, MS | USM | USM |
| Ball State | Western Michigan | Waldo Stadium, Kalamazoo, MI | WMU | WMU |
| Coastal Carolina | Louisiana Monroe | Malone Stadium, Monroe, LA | ULM | ULM |
| Air Force | New Mexico | Dreamstyle Stadium, Albuquerque, NM | Air Force | AF |
| Memphis | UCF | Spectrum Stadium, Orlando, FL | Memphis | Memphis |
| #11 Ohio State | Rutgers | High Point Solutions Stadium, Piscataway, NJ | Ohio St | OSU |
| South Carolina | Texas A&M | Kyle Field, College Station, TX | A&M | TAMU |
| #2 Clemson | #12 Virginia Tech | Lane Stadium, Blacksburg, VA | Clemson | Va Tech |
| #6 Washington | Oregon State | Reser Stadium, Corvallis, OR | Washington | Washington |
| #15 Oklahoma State | Texas Tech | Jones AT&T Stadium, Lubbock, TX | OK State | Ok State |
| Ole Miss | #1 Alabama | Bryant-Denny Stadium, Tuscaloosa, AL | Alabama | Alabama |
| Nevada | Fresno State | Bulldog Stadium , Fresno, CA | Fresno St | Fresno ST |
| Northern Illinois | #19 San Diego State | Qualcomm Stadium, San Diego, CA | SDSU | SDSU |
| San José State | UNLV | Sam Boyd Stadium, Las Vegas, NV | UNLV | UNLV |
| Colorado | UCLA | Rose Bowl, Pasadena, CA | Colorado | UCLA |
| California | Oregon | Autzen Stadium, Eugene, OR | Oregon | Oregon |
| Colorado State | Hawai’i | Aloha Stadium, Honolulu, HI | Colorado St | CSU |
| Gameday Guest Picker (Blacksburg) | Frank Beamer | Mike Vick | ||
| Total picks right | 231 | 244 |
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