Three weeks are in the books for college football and things have officially been shaken up. After three weeks of making picks for every FBS college football game, Joe DiTullio and Rob Doerger make their picks for week 4.
| Away | Home | Location | Rob | Joe |
| Temple | #21 South Florida | Raymond James Stadium, Tampa, FL | USF | USF |
| Virginia | Boise State | Albertsons Stadium, Boise, ID | Boise | Boise |
| #23 Utah | Arizona | Arizona Stadium, Tucson, AZ | Arizona | Utah |
| UNLV | #10 Ohio State | Ohio Stadium, Columbus, OH | Ohio St | Ohio State |
| Margin of Victory | 44 | 40 | ||
| NC State | #12 Florida State | Doak Campbell Stadium, Tallahassee, FL | FSU | FSU |
| Kent State | #19 Louisville | Papa John’s Cardinal Stadium, Louisville, KY | Louisville | Louisville |
| Texas Tech | Houston | TDECU Stadium, Houston, TX | Houston | Houston |
| Army | Tulane | Yulman Stadium, New Orleans, LA | Tulane | Tulane |
| Texas A&M | Arkansas | AT&T Stadium, Arlington, TX | Arkansas | Arkansas |
| UMass | Tennessee | Neyland Stadium, Knoxville, TN | Tennessee | Tennessee |
| West Virginia | Kansas | Memorial Stadium , Lawrence, KS | WVU | WVU |
| Pittsburgh | Georgia Tech | Bobby Dodd Stadium, Atlanta, GA | GT | GT |
| New Mexico | Tulsa | Chapman Stadium, Tulsa, OK | Tulsa | Tulsa |
| Old Dominion | #13 Virginia Tech | Lane Stadium, Blacksburg, VA | VT | Va Tech |
| Idaho | South Alabama | Ladd-Peebles Stadium, Mobile, AL | USA | USA |
| Ohio | Eastern Michigan | Rynearson Stadium, Ypsilanti, MI | EMU | Ohio |
| UCF | Maryland | Maryland Stadium, College Park, MD | Maryland | Maryland |
| #1 Alabama | Vanderbilt | Vanderbilt Stadium, Nashville, TN | Alabama | Alabama |
| Boston College | #2 Clemson | Memorial Stadium , Clemson, SC | Clemson | Clemson |
| #5 USC | California | Memorial Stadium , Berkeley, CA | USC | USC |
| #16 TCU | #6 Oklahoma State | Boone Pickens Stadium, Stillwater, OK | OK State | Ok State |
| Toledo | #14 Miami | Hard Rock Stadium, Miami, FL | Toledo | Miami |
| Rutgers | Nebraska | Memorial Stadium , Lincoln, NE | Nebraska | Nebraska |
| Georgia Southern | Indiana | Memorial Stadium , Bloomington, IN | Indiana | Indiana |
| Wake Forest | Appalachian State | Kidd Brewer Stadium, Boone, NC | Wake | App St |
| Duke | North Carolina | Kenan Stadium, Chapel Hill, NC | Duke | Duke |
| Louisiana Tech | South Carolina | Williams-Brice Stadium, Columbia, SC | La Tech | South Carolina |
| Miami (OH) | Central Michigan | Kelly/Shorts Stadium, Mount Pleasant, MI | CMU | Miami |
| Cincinnati | Navy | Navy-Marine Corps Memorial Stadium, Annapolis, MD | Navy | Navy |
| #8 Michigan | Purdue | Ross-Ade Stadium, West Lafayette, IN | Michigan | Michigan |
| Louisiana Monroe | Louisiana | Cajun Field, Lafayette, LA | ULL | ULL |
| Nevada | #18 Washington State | Martin Stadium, Pullman, WA | Wash St | Wazzu |
| Akron | Troy | Veterans Memorial Stadium , Troy, AL | Troy | Troy |
| Georgia State | Charlotte | McColl-Richardson Field, Charlotte, NC | Georgia St | Georgia St |
| #3 Oklahoma | Baylor | McLane Stadium, Waco, TX | Oklahoma | Oklahoma |
| Western Illinois | Coastal Carolina | Brooks Stadium, Conway, SC | Coastal | Coastal |
| UAB | North Texas | Apogee Stadium, Denton, TX | UNT | UNT |
| #17 Mississippi State | #11 Georgia | Sanford Stadium, Athens, GA | Miss State | Georgia |
| #22 San Diego State | Air Force | Falcon Stadium, Usaf Academy, CO | SDSU | SDSU |
| Syracuse | #25 LSU | Tiger Stadium , Baton Rouge, LA | LSU | LSU |
| Ball State | Western Kentucky | L.T. Smith Stadium, Bowling Green, KY | WKU | WKU |
| Florida Atlantic | Buffalo | UB Stadium, Buffalo, NY | Buffalo | Buffalo |
| Bowling Green | Middle Tennessee | Floyd Stadium, Murfreesboro, TN | MTSU | MTSU |
| Arkansas State | SMU | Gerald J. Ford Stadium, Dallas, TX | SMU | SMU |
| Wagner | Western Michigan | Waldo Stadium, Kalamazoo, MI | WMU | WMU |
| #4 Penn State | Iowa | Kinnick Stadium, Iowa City, IA | Penn St | Penn State |
| #15 Auburn | Missouri | Memorial Stadium/Faurot Field, Columbia, MO | Auburn | Auburn |
| #20 Florida | Kentucky | Commonwealth Stadium, Lexington, KY | Florida | Florida |
| Florida Intl | Rice | Rice Stadium, Houston, TX | Rice | Rice |
| Utah State | San José State | CEFCU Stadium – Home of the Spartans, San Jose, CA | Utah ST | Utah St |
| UT San Antonio | Texas State | Bobcat Stadium , San Marcos, TX | UTSA | UTSA |
| UTEP | New Mexico State | Aggie Memorial Stadium, Las Cruces, NM | NMSU | NMSU |
| Southern Illinois | Memphis | Liberty Bowl Memorial Stadium, Memphis, TN | Memphis | Memphis |
| Notre Dame | Michigan State | Spartan Stadium , East Lansing, MI | ND | ND |
| #7 Washington | Colorado | Folsom Field, Boulder, CO | Washington | Washington |
| #24 Oregon | Arizona State | Sun Devil Stadium, Tempe, AZ | Oregon | Oregon |
| Hawai’i | Wyoming | War Memorial Stadium , Laramie, WY | Wyoming | Wyoming |
| UCLA | Stanford | Stanford Stadium, Stanford, CA | Stanford | Stanford |
| East Carolina | Connecticut | Rentschler Field, East Hartford, CT | Uconn | Uconn |
| Gameday Guest Picker (New York City) | Bruno Mars | Lin-Manuel Miranda | ||
| Total picks correct | 187 | 195 |
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