Joe DiTullio and Rob Doerger make their college football picks for week 10 including all games that include FBS teams.
| Away | Home | Location | Rob | Joe |
| Bowling Green | Kent State | Dix Stadium, Kent, OH | Kent St | Kent St |
| Miami (OH) | Ohio | Peden Stadium, Athens, OH | Ohio | Ohio |
| Central Michigan | Western Michigan | Waldo Stadium, Kalamazoo, MI | WMU | WMU |
| Northern Illinois | Toledo | Glass Bowl, Toledo, OH | Toledo | Toledo |
| Ball State | Eastern Michigan | Rynearson Stadium, Ypsilanti, MI | EMU | EMU |
| Navy | Temple | Lincoln Financial Field, Philadelphia, PA | Navy | Navy |
| Idaho | Troy | Veterans Memorial Stadium , Troy, AL | Troy | Troy |
| Marshall | Florida Atlantic | FAU Football Stadium, Boca Raton, FL | FAU | Marshall |
| #22 Memphis | Tulsa | Chapman Stadium, Tulsa, OK | Memphis | Memphis |
| UCLA | Utah | Rice-Eccles Stadium, Salt Lake City, UT | Utah | Utah |
| #4 Wisconsin | Indiana | Memorial Stadium , Bloomington, IN | Wisconsin | Wisconsin |
| #7 Penn State | #24 Michigan State | Spartan Stadium , East Lansing, MI | Penn St | PSU |
| #16 Auburn | Texas A&M | Kyle Field, College Station, TX | Auburn | Auburn |
| UMass | #21 Mississippi State | Davis Wade Stadium, Starkville, MS | Miss State | Miss St |
| Margin of victory | 28 | 33 | ||
| Florida | Missouri | Memorial Stadium/Faurot Field, Columbia, MO | Mizzou | Florida |
| Kansas State | Texas Tech | Jones AT&T Stadium, Lubbock, TX | Texas Tech | TT |
| Western Kentucky | Vanderbilt | Vanderbilt Stadium, Nashville, TN | Vandy | Vandy |
| Baylor | Kansas | Memorial Stadium , Lawrence, KS | Kansas? | Baylor |
| Illinois | Purdue | Ross-Ade Stadium, West Lafayette, IN | Purdue | Purdue |
| East Carolina | Houston | TDECU Stadium, Houston, TX | Houston | Houston |
| Syracuse | Florida State | Doak Campbell Stadium, Tallahassee, FL | Syracuse | Cuse |
| Georgia Tech | Virginia | Scott Stadium, Charlottesville, VA | GT | GT |
| Appalachian State | Louisiana Monroe | Malone Stadium, Monroe, LA | App St | App St |
| Georgia State | Georgia Southern | Allen E. Paulson Stadium, Statesboro, GA | Georgia St | Ga State |
| Rice | UAB | Legion Field , Birmingham, AL | UAB | UAB |
| New Mexico State | Texas State | Bobcat Stadium , San Marcos, TX | New Mex St | NMSU |
| South Carolina | #1 Georgia | Sanford Stadium, Athens, GA | Georgia | UGA |
| #3 Ohio State | Iowa | Kinnick Stadium, Iowa City, IA | OSU | OSU |
| Wake Forest | #5 Notre Dame | Notre Dame Stadium, Notre Dame, IN | ND | ND |
| #6 Clemson | #20 NC State | Carter-Finley Stadium, Raleigh, NC | Clemson | Clemson |
| #14 Iowa State | West Virginia | Milan Puskar Stadium, Morgantown, WV | WVU | WVU |
| #18 Stanford | #25 Washington State | Martin Stadium, Pullman, WA | Wash St | Wazzu |
| South Florida | Connecticut | Rentschler Field, East Hartford, CT | USF | USF |
| Maryland | Rutgers | High Point Solutions Stadium, Piscataway, NJ | Maryland | Maryland |
| Charlotte | Old Dominion | S.B. Ballard Stadium, Norfolk, VA | Old Dom | ODU |
| North Texas | Louisiana Tech | Joe Aillet Stadium, Ruston, LA | UNT | La Tech |
| Northwestern | Nebraska | Memorial Stadium , Lincoln, NE | Nebraska | NW |
| Army | Air Force | Falcon Stadium, Usaf Academy, CO | Air Force | AF |
| #8 Oklahoma | #11 Oklahoma State | Boone Pickens Stadium, Stillwater, OK | Oklahoma | Oklahoma |
| Ole Miss | Kentucky | Commonwealth Stadium, Lexington, KY | Kentucky | Kentucky |
| Coastal Carolina | Arkansas | Razorback Stadium, Fayetteville, AR | Arkansas | Arkansas |
| Cincinnati | Tulane | Yulman Stadium, New Orleans, LA | Tulane | Tulane |
| Louisiana | South Alabama | Ladd-Peebles Stadium, Mobile, AL | USA | USA |
| Oregon State | California | Memorial Stadium , Berkeley, CA | Cal | Cal |
| Utah State | New Mexico | Dreamstyle Stadium, Albuquerque, NM | New Mexico | NM |
| Hawai’i | UNLV | Sam Boyd Stadium, Las Vegas, NV | Hawai’i | Hawai’i |
| Nevada | Boise State | Albertsons Stadium, Boise, ID | Boise | Boise |
| Colorado State | Wyoming | War Memorial Stadium , Laramie, WY | Col St | Colorado St |
| UT San Antonio | Florida Intl | FIU Stadium, Miami, FL | FIU | UTSA |
| Texas | #10 TCU | Amon G. Carter Stadium, Fort Worth, TX | TCU | TCU |
| #15 UCF | SMU | Gerald J. Ford Stadium, Dallas, TX | UCF | UCF |
| Southern Mississippi | Tennessee | Neyland Stadium, Knoxville, TN | So Miss | So Miss |
| UTEP | Middle Tennessee | Floyd Stadium, Murfreesboro, TN | MTSU | MTSU |
| Minnesota | Michigan | Michigan Stadium, Ann Arbor, MI | Michigan | Michigan |
| #19 LSU | #1 Alabama | Bryant-Denny Stadium, Tuscaloosa, AL | Alabama | Alabama |
| #13 Virginia Tech | #9 Miami | Hard Rock Stadium, Miami, FL | Va Tech | Va Tech |
| Colorado | Arizona State | Sun Devil Stadium, Tempe, AZ | Arizona St | ASU |
| Oregon | #12 Washington | Husky Stadium, Seattle, WA | Washington | Washington |
| San Diego State | San Jose State | CEFCU Stadium – Home of the Spartans, San Jose, CA | SDSU | SDSU |
| #23 Arizona | #17 USC | Los Angeles Memorial Coliseum, Los Angeles, CA | Arizona | Zona |
| BYU | Fresno State | Bulldog Stadium , Fresno, CA | Fresno | Fresno |
| Gameday Guest Picker (Stillwater) | Big Country Reeves | Barry Sanders |
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