The college basketball season has started! There are plenty of big games that will be picked this year. Here are college basketball picks week of November 21.
| Away | Home | Joe |
| Texas Tech | Creighton | Creighton |
| Louisville | Arkansas | Arkansas |
| Omaha | Iowa | Iowa |
| Northern Arizona | Texas | Texas |
| Bellarmine | Duke | Duke |
| Ohio State | San Diego State | Ohio State |
| Cincinnati | Arizona | Arizona |
| Texas Tech | Louisville | Texas Tech |
| Auburn | Bradley | Auburn |
| Creighton | Arkansas | Arkansas |
| San Diego State | Arizona | Arizona |
| NC State | Kansas | Kansas |
| McNeese | Baylor | Baylor |
| North Florida | Kentucky | Kentucky |
| Little Rock | Indiana | Indiana |
| Butler | Tennessee | Tennessee |
| Pepperdine | UCLA | UCLA |
| North Carolina | Portland | UNC |
| Duke | Oregon State | Duke |
| UConn | Oregon | UConn |
| Purdue | West Virginia | West Virginia |
| Alabama | Michigan State | Alabama |
| Portland State | Gonzaga | Gonzaga |
| Jackson State | Indiana | Indiana |
| Coppin State | Maryland | Maryland |
| Maryland-Eastern Shore | Virginia | Virginia |
| Iowa | Clemson | Iowa |
| Lindenwood | Illinois | Illinois |
| Kent State | Houston | Houston |
| UT Rio Grande Valley | Texas | Texas |
| Saint Louis | Auburn | Saint Louis |
| Bellarmine | UCLA | UCLA |
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