The college basketball season has started! There are plenty of big games that will be picked this year. Here are college basketball picks week of January 22.
Note: These are moneyline picks. There will be a new picks article every week.
| Away | Home | Joe |
| Wake Forest | North Carolina | UNC |
| Cincinnati | Kansas | Kansas |
| Dayton | LaSalle | Dayton |
| Kentucky | South Carolina | UK |
| Texas | Oklahoma | Texas |
| Duke | Louisville | Duke |
| Wisconsin | Minnesota | Wisconsin |
| Xavier | Creighton | Creighton |
| Michigan | Purdue | Purdue |
| Houston | BYU | Houston |
| Auburn | Alabama | Auburn |
| Florida Atlantic | Rice | FAU |
| Illinois | Northwestern | Illinois |
| Marquette | DePaul | Marquette |
| Kansas State | Iowa State | Iowa State |
| Colorado State | Nevada | Colorado State |
| New Mexico | San Jose State | New Mexico |
| Arizona | Oregon State | Zona |
| Michigan State | Wisconsin | Wisconsin |
| Kansas State | Houston | Houston |
| Seton Hall | Marquette | Marquette |
| Kansas | Iowa State | Kansas |
| North Carolina | Florida State | UNC |
| Texas Tech | Oklahoma | Oklahoma |
| Texas | BYU | Texas |
| Indiana | Illinois | Illinois |
| Auburn | Mississippi State | Auburn |
| Clemson | Duke | Clemson |
| TCU | Baylor | Baylor |
| Utah State | Boise State | Boise |
| Colorado State | Wyoming | Colorado State |
| Arizona | Oregon | Zona |
| Tennessee | Vanderbilt | Tennessee |
| Kentucky | Arkansas | Kentucky |
| Dayton | Richmond | Dayton |
| DePaul | Creighton | Creighton |
| Xavier | UConn | UConn |
| Purdue | Rutgers | Purdue |
| North Texas | Florida Atlantic | FAU |
| Memphis | UAB | Memphis |
| Nevada | New Mexico | New Mexico |
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